Microbial phenotypic heterogeneity in response to a metabolic toxin: Continuous, dynamically shifting distribution of formaldehyde tolerance in Methylobacterium extorquens populations

• Jessica A. Lee ,

  Contributed equally to this work with: Jessica A. Lee, Siavash Riazi

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  * E-mail: jessica.audrey.lee@gmail.com (JAL); cmarx@uidaho.edu (CJM)

  Affiliations Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America, Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, United States of America, Global Viral, San Francisco, California, United States of America

  http://orcid.org/0000-0002-0250-4064

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• Siavash Riazi ,

  Contributed equally to this work with: Jessica A. Lee, Siavash Riazi

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – review & editing

  Affiliations Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, United States of America, Bioinformatics and Computational Biology Graduate Program, University of Idaho, Moscow, Idaho, United States of America

  http://orcid.org/0000-0002-1826-7104

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• Shahla Nemati,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliations Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Department of Physics, University of Idaho, Moscow, Idaho, United States of America

  http://orcid.org/0000-0003-1305-5185

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• Jannell V. Bazurto,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America, Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, United States of America, Department of Plant and Microbial Biology, University of Minnesota, Twin Cities, Minnesota, United States of America, Microbial and Plant Genomics Institute, University of Minnesota, Twin Cities, Minnesota, United States of America

  http://orcid.org/0000-0001-9012-2260

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• Andreas E. Vasdekis,

  Roles Funding acquisition, Investigation, Visualization, Writing – review & editing

  Affiliations Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, United States of America, Department of Physics, University of Idaho, Moscow, Idaho, United States of America

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• Benjamin J. Ridenhour,

  Roles Formal analysis, Software, Supervision, Writing – review & editing

  Affiliations Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, United States of America, Department of Mathematics, University of Idaho, Moscow, Idaho, United States of America

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• Christopher H. Remien,

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Department of Mathematics, University of Idaho, Moscow, Idaho, United States of America

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• Christopher J. Marx

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: jessica.audrey.lee@gmail.com (JAL); cmarx@uidaho.edu (CJM)

  Affiliations Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America, Center for Modeling Complex Interactions, University of Idaho, Moscow, Idaho, United States of America, Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, United States of America

  http://orcid.org/0000-0002-5189-4580

  ⨯