Low affinity binding sites in an activating CRM mediate negative autoregulation of the Drosophila Hox gene Ultrabithorax

• Rebecca K. Delker ,

  Contributed equally to this work with: Rebecca K. Delker, Vikram Ranade

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Biophysics and Systems Biology, Columbia University, New York, NY, United States of America, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States of America

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• Vikram Ranade ,

  Contributed equally to this work with: Rebecca K. Delker, Vikram Ranade

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Department of Genetics, Columbia University, New York, NY, United States of America

  ⨯
• Ryan Loker,

  Roles Investigation, Methodology

  Affiliation Department of Genetics, Columbia University, New York, NY, United States of America

  ⨯
• Roumen Voutev,

  Roles Investigation, Methodology

  Affiliations Department of Biochemistry and Molecular Biophysics and Systems Biology, Columbia University, New York, NY, United States of America, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States of America

  http://orcid.org/0000-0003-0066-4731

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• Richard S. Mann

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rsm10@columbia.edu

  Affiliations Department of Biochemistry and Molecular Biophysics and Systems Biology, Columbia University, New York, NY, United States of America, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States of America

  http://orcid.org/0000-0002-4749-2765

  ⨯