DNA variants affecting the expression of numerous genes in trans have diverse mechanisms of action and evolutionary histories

• Sheila Lutz,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN, United States of America

  http://orcid.org/0000-0002-6729-4598

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• Christian Brion,

  Roles Conceptualization, Formal analysis, Visualization, Writing – review & editing

  Affiliation Department of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN, United States of America

  http://orcid.org/0000-0002-3548-1401

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• Margaret Kliebhan,

  Roles Formal analysis, Software

  Affiliation Department of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN, United States of America

  http://orcid.org/0000-0003-4358-7238

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• Frank W. Albert

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: falbert@umn.edu

  Affiliation Department of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN, United States of America

  http://orcid.org/0000-0002-1380-8063

  ⨯