Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

• Victoria J. Butler,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0002-1693-871X

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• Fuying Gao,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-5798-7948

  ⨯
• Christian I. Corrales,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0001-6269-9337

  ⨯
• Wilian A. Cortopassi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0001-8038-7847

  ⨯
• Benjamin Caballero,

  Roles Methodology

  Affiliation Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York, United States of America

  ⨯
• Mihir Vohra,

  Roles Data curation, Methodology

  Affiliation Department of Physiology, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0002-0032-5708

  ⨯
• Kaveh Ashrafi,

  Roles Funding acquisition, Methodology

  Affiliation Department of Physiology, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0002-5887-0346

  ⨯
• Ana Maria Cuervo,

  Roles Funding acquisition, Methodology, Writing – review & editing

  Affiliation Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York, United States of America

  ⨯
• Matthew P. Jacobson,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0001-6262-655X

  ⨯
• Giovanni Coppola,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology

  Affiliation Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

  ⨯
• Aimee W. Kao

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: aimee.kao@ucsf.edu

  Affiliation Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, United States of America

  ⨯