Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo

Aleksandra Pajak; Isabelle Laine; Paula Clemente; Najla El-Fissi; Florian A. Schober; Camilla Maffezzini; Javier Calvo-Garrido; Rolf Wibom; Roberta Filograna; Ashish Dhir; Anna Wedell; Christoph Freyer; Anna Wredenberg

doi:10.1371/journal.pgen.1008240

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Open Access

Peer-reviewed

Research Article

Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo

Aleksandra Pajak ,

Contributed equally to this work with: Aleksandra Pajak, Isabelle Laine

Roles Formal analysis, Investigation, Project administration, Writing – original draft

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden

http://orcid.org/0000-0001-8294-9620

⨯
Isabelle Laine ,

Contributed equally to this work with: Aleksandra Pajak, Isabelle Laine

Roles Formal analysis, Investigation, Writing – original draft

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden
⨯
Paula Clemente,

Roles Formal analysis, Methodology

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden

http://orcid.org/0000-0002-6885-3750

⨯
Najla El-Fissi,

Roles Methodology

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden
⨯
Florian A. Schober,

Roles Data curation, Formal analysis

Affiliations Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

http://orcid.org/0000-0003-4604-6170

⨯
Camilla Maffezzini,

Roles Formal analysis

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden

http://orcid.org/0000-0002-0397-1609

⨯
Javier Calvo-Garrido,

Roles Methodology

Affiliations Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
⨯
Rolf Wibom,

Roles Methodology

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden

http://orcid.org/0000-0001-6721-4642

⨯
Roberta Filograna,

Roles Methodology

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden
⨯
Ashish Dhir,

Roles Methodology

Affiliation Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
⨯
Anna Wedell,

Roles Funding acquisition, Resources, Supervision

Affiliations Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden
⨯
Christoph Freyer ,

Roles Conceptualization, Resources, Supervision, Visualization, Writing – original draft

* E-mail: christoph.freyer@ki.se (CF); anna.wredenberg@ki.se (AW)

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden, Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden

http://orcid.org/0000-0003-0418-1673

⨯
Anna Wredenberg

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: christoph.freyer@ki.se (CF); anna.wredenberg@ki.se (AW)

Affiliations Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden, Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden

http://orcid.org/0000-0002-2500-6121

⨯

Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo

Aleksandra Pajak,
Isabelle Laine,
Paula Clemente,
Najla El-Fissi,
Florian A. Schober,
Camilla Maffezzini,
Javier Calvo-Garrido,
Rolf Wibom,
Roberta Filograna,
Ashish Dhir

Published: July 31, 2019
https://doi.org/10.1371/journal.pgen.1008240

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Antisense RNA
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Double stranded RNA
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