Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals

• Shira Perez ,

  Contributed equally to this work with: Shira Perez, Antony Kaspi, Tom Domovitz

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Molecular Virology Lab, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel, Cancer Personalized Medicine and Diagnostic Genomics Lab, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

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• Antony Kaspi ,

  Contributed equally to this work with: Shira Perez, Antony Kaspi, Tom Domovitz

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Epigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia

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• Tom Domovitz ,

  Contributed equally to this work with: Shira Perez, Antony Kaspi, Tom Domovitz

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Molecular Virology Lab, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

  ⨯
• Ateret Davidovich,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization

  Affiliation Molecular Virology Lab, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

  ⨯
• Anat Lavi-Itzkovitz,

  Roles Formal analysis, Software

  Affiliations Molecular Virology Lab, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel, Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat-Gan, Israel

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• Tomer Meirson,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Drug Discovery Laboratory, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

  http://orcid.org/0000-0002-5011-5477

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• Jacinta Alison Holmes,

  Roles Resources

  Affiliation Liver Center, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Chia-Yen Dai,

  Roles Resources

  Affiliations Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Chung-Feng Huang,

  Roles Resources

  Affiliations Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Raymond T. Chung,

  Roles Funding acquisition, Resources

  Affiliation Liver Center, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Assy Nimer,

  Roles Resources

  Affiliation Internal Medicine Department A, Western Galilee Medical Center, Naharyia, and Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

  ⨯
• Assam El-Osta,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Epigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia, Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR

  http://orcid.org/0000-0001-7968-7375

  ⨯
• Gur Yaari,

  Roles Formal analysis, Software

  Affiliation Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat-Gan, Israel

  http://orcid.org/0000-0001-9311-9884

  ⨯
• Salomon M. Stemmer,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision

  Affiliation Davidoff Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

  ⨯
• Ming-Lung Yu ,

  Roles Data curation, Project administration, Resources, Supervision

  * E-mail: fish6069@gmail.com (MLY); Izhak.Haviv@biu.ac.il (IH); Meital.Tanamy@biu.ac.il (MGT)

  Affiliations Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung, Taiwan, College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

  http://orcid.org/0000-0001-8145-1900

  ⨯
• Izhak Haviv ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fish6069@gmail.com (MLY); Izhak.Haviv@biu.ac.il (IH); Meital.Tanamy@biu.ac.il (MGT)

  Affiliation Cancer Personalized Medicine and Diagnostic Genomics Lab, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

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•  [ ... ],
• Meital Gal-Tanamy

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fish6069@gmail.com (MLY); Izhak.Haviv@biu.ac.il (IH); Meital.Tanamy@biu.ac.il (MGT)

  Affiliation Molecular Virology Lab, Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

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