Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I

Tommy Darrière; Michael Pilsl; Marie-Kerguelen Sarthou; Adrien Chauvier; Titouan Genty; Sylvain Audibert; Christophe Dez; Isabelle Léger-Silvestre; Christophe Normand; Anthony K. Henras; Marta Kwapisz; Olga Calvo; Carlos Fernández-Tornero; Herbert Tschochner; Olivier Gadal

doi:10.1371/journal.pgen.1008157

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Open Access

Peer-reviewed

Research Article

Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I

Tommy Darrière,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France

http://orcid.org/0000-0002-1655-525X

⨯
Michael Pilsl,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Universität Regensburg, Biochemie-Zentrum Regensburg (BZR), Lehrstuhl Biochemie III, Regensburg, Germany
⨯
Marie-Kerguelen Sarthou,

Roles Investigation

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
⨯
Adrien Chauvier,

Roles Investigation

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France

http://orcid.org/0000-0003-4473-6194

⨯
Titouan Genty,

Roles Investigation

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
⨯
Sylvain Audibert,

Roles Investigation

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France

http://orcid.org/0000-0002-4414-1345

⨯
Christophe Dez,

Roles Conceptualization, Data curation, Investigation, Validation, Writing – review & editing

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France

http://orcid.org/0000-0002-8526-3541

⨯
Isabelle Léger-Silvestre,

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France

http://orcid.org/0000-0002-7030-5593

⨯
Christophe Normand,

Roles Conceptualization, Formal analysis, Investigation, Software, Validation

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France

http://orcid.org/0000-0001-6104-1285

⨯
Anthony K. Henras,

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
⨯
Marta Kwapisz,

Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
⨯
Olga Calvo,

Roles Investigation, Resources

Affiliation Instituto de Biología Funcional y Genómica, IBFG-CSIC, Universidad de Salamanca, Salamanca, Spain

http://orcid.org/0000-0002-9786-7916

⨯
Carlos Fernández-Tornero,

Roles Conceptualization, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

http://orcid.org/0000-0001-5097-731X

⨯
Herbert Tschochner,

Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliation Universität Regensburg, Biochemie-Zentrum Regensburg (BZR), Lehrstuhl Biochemie III, Regensburg, Germany

http://orcid.org/0000-0002-3560-861X

⨯
Olivier Gadal

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft

* E-mail: olivier.gadal@ibcg.biotoul.fr

Affiliation Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France

http://orcid.org/0000-0001-9421-0831

⨯

Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I

Tommy Darrière,
Michael Pilsl,
Marie-Kerguelen Sarthou,
Adrien Chauvier,
Titouan Genty,
Sylvain Audibert,
Christophe Dez,
Isabelle Léger-Silvestre,
Christophe Normand,
Anthony K. Henras

Published: May 28, 2019
https://doi.org/10.1371/journal.pgen.1008157
See the preprint

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RNA polymerase
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