An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape

• Victoria O. Pokusaeva ,

  Contributed equally to this work with: Victoria O. Pokusaeva, Dinara R. Usmanova, Ekaterina V. Putintseva

  Roles Conceptualization, Formal analysis, Methodology

  Affiliation Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria

  http://orcid.org/0000-0001-7660-444X

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• Dinara R. Usmanova ,

  Contributed equally to this work with: Victoria O. Pokusaeva, Dinara R. Usmanova, Ekaterina V. Putintseva

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Systems Biology, Columbia University, New York, NY, United States of America

  http://orcid.org/0000-0001-5031-0013

  ⨯
• Ekaterina V. Putintseva ,

  Contributed equally to this work with: Victoria O. Pokusaeva, Dinara R. Usmanova, Ekaterina V. Putintseva

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization

  Affiliation Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria

  http://orcid.org/0000-0003-4421-3844

  ⨯
• Lorena Espinar,

  Roles Methodology, Project administration

  Affiliations Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 88 Dr. Aiguader, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain

  http://orcid.org/0000-0003-3881-3886

  ⨯
• Karen S. Sarkisyan,

  Roles Data curation, Methodology

  Affiliations Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia, Medical Research Council London Institute of Medical Sciences, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0002-5375-6341

  ⨯
• Alexander S. Mishin,

  Roles Formal analysis

  Affiliation Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

  http://orcid.org/0000-0002-4935-7030

  ⨯
• Natalya S. Bogatyreva,

  Roles Formal analysis

  Affiliations Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 88 Dr. Aiguader, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, Pushchino, Moscow region, Russia

  ⨯
• Dmitry N. Ivankov,

  Roles Formal analysis

  Affiliations Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria, Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, Pushchino, Moscow region, Russia

  ⨯
• Arseniy V. Akopyan,

  Roles Formal analysis

  Affiliation Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria

  http://orcid.org/0000-0002-2548-617X

  ⨯
• Sergey Ya. Avvakumov,

  Roles Formal analysis

  Affiliation Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria

  ⨯
• Inna S. Povolotskaya,

  Roles Conceptualization

  Affiliation Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia

  http://orcid.org/0000-0001-6621-232X

  ⨯
• Guillaume J. Filion,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation

  Affiliations Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 88 Dr. Aiguader, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain

  http://orcid.org/0000-0002-3473-1632

  ⨯
• Lucas B. Carey ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: lucas.carey@gmail.com (LBC); fyodor.kondrashov@ist.ac.at (FAK)

  Affiliations Universitat Pompeu Fabra (UPF), Barcelona, Spain, Center for Quantitative Biology and Peking-Tsinghua Joint Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

  ⨯
• Fyodor A. Kondrashov

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lucas.carey@gmail.com (LBC); fyodor.kondrashov@ist.ac.at (FAK)

  Affiliation Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria

  http://orcid.org/0000-0001-8243-4694

  ⨯