Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

• Dirk Schumacher,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

  http://orcid.org/0000-0002-0031-0063

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• Geoffroy Andrieux,

  Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – review & editing

  Affiliations German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany

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• Karsten Boehnke,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Eli Lilly and Company, Lilly Research Laboratories, Oncology Translational Research, New York, NY, United States of America

  http://orcid.org/0000-0001-6582-5722

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• Marlen Keil,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation EPO Experimental Pharmacology and Oncology Berlin-Buch GmbH, Berlin, Germany

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• Alessandra Silvestri,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation cpo—Cellular Phenomics & Oncology Berlin-Buch GmbH, Berlin, Germany

  http://orcid.org/0000-0003-4891-1826

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• Maxine Silvestrov,

  Roles Investigation

  Affiliation cpo—Cellular Phenomics & Oncology Berlin-Buch GmbH, Berlin, Germany

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• Ulrich Keilholz,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Charité Comprehensive Cancer Center, Berlin, Germany

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• Johannes Haybaeck,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliations Department of Pathology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, Department of Pathology, Neuropathology, and Molecular Pathology, Medical University of Innsbruck, Austria, Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, Austria

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• Gerrit Erdmann,

  Roles Formal analysis, Software, Visualization, Writing – review & editing

  Affiliations NMI TT Pharmaservices, Berlin, Germany, ASC Oncology GmbH, Berlin, Germany

  http://orcid.org/0000-0002-4183-3995

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• Christoph Sachse,

  Roles Formal analysis, Investigation, Software, Validation, Visualization, Writing – review & editing

  Affiliations NMI TT Pharmaservices, Berlin, Germany, ASC Oncology GmbH, Berlin, Germany

  http://orcid.org/0000-0001-9988-9388

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• Markus Templin,

  Roles Formal analysis, Resources, Supervision, Visualization, Writing – review & editing

  Affiliations ASC Oncology GmbH, Berlin, Germany, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany

  http://orcid.org/0000-0002-6569-6489

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• Jens Hoffmann,

  Roles Data curation, Formal analysis, Funding acquisition, Resources, Writing – review & editing

  Affiliation EPO Experimental Pharmacology and Oncology Berlin-Buch GmbH, Berlin, Germany

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• Melanie Boerries,

  Roles Data curation, Formal analysis, Software, Supervision, Visualization, Writing – review & editing

  Affiliations German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany

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• Reinhold Schäfer ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: reinhold.schaefer@charite.de (RS); christian.regenbrecht@asc-oncology.eu (CRAR)

  Affiliations German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, Charité Comprehensive Cancer Center, Berlin, Germany

  http://orcid.org/0000-0001-7952-2124

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• Christian R. A. Regenbrecht

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: reinhold.schaefer@charite.de (RS); christian.regenbrecht@asc-oncology.eu (CRAR)

  Affiliations cpo—Cellular Phenomics & Oncology Berlin-Buch GmbH, Berlin, Germany, Department of Pathology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, ASC Oncology GmbH, Berlin, Germany

  http://orcid.org/0000-0001-9494-5977

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