Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals

• Hanna Shin ,

  Contributed equally to this work with: Hanna Shin, Christian Braendle, Kimberly B. Monahan, Rebecca E. W. Kaplan

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Institute of Biosciences and Technology, Texas A&M Health Science Center, Texas A&M University, Houston, TX, United States of America

  ⨯
• Christian Braendle ,

  Contributed equally to this work with: Hanna Shin, Christian Braendle, Kimberly B. Monahan, Rebecca E. W. Kaplan

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Université Côte d’Azur, CNRS, Inserm, IBV, Nice, France

  http://orcid.org/0000-0003-0203-4581

  ⨯
• Kimberly B. Monahan ,

  Contributed equally to this work with: Hanna Shin, Christian Braendle, Kimberly B. Monahan, Rebecca E. W. Kaplan

  Roles Formal analysis, Investigation

  Affiliation Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America

  ⨯
• Rebecca E. W. Kaplan ,

  Contributed equally to this work with: Hanna Shin, Christian Braendle, Kimberly B. Monahan, Rebecca E. W. Kaplan

  Roles Investigation

  Affiliation Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America

  ⨯
• Tanya P. Zand,

  Roles Investigation

  Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America, Department of Pharmacology, University of North Carolina, Chapel Hill, NC, United States of America

  http://orcid.org/0000-0001-8729-5849

  ⨯
• Francisca Sefakor Mote,

  Roles Investigation

  Affiliation Institute of Biosciences and Technology, Texas A&M Health Science Center, Texas A&M University, Houston, TX, United States of America

  ⨯
• Eldon C. Peters,

  Roles Investigation

  Affiliation Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America

  ⨯
• David J. Reiner

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: dreiner@ibt.tamhsc.edu

  Affiliations Institute of Biosciences and Technology, Texas A&M Health Science Center, Texas A&M University, Houston, TX, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America, Department of Pharmacology, University of North Carolina, Chapel Hill, NC, United States of America

  http://orcid.org/0000-0002-0344-7161

  ⨯