Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis

Zhixiu Li; Servet Akar; Handan Yarkan; Sau Kuen Lee; Pınar Çetin; Gerçek Can; Gökce Kenar; Fernur Çapa; Omer Nuri Pamuk; Yavuz Pehlivan; Katie Cremin; Erika De Guzman; Jessica Harris; Lawrie Wheeler; Ahmadreza Jamshidi; Mahdi Vojdanian; Elham Farhadi; Nooshin Ahmadzadeh; Zeynep Yüce; Ediz Dalkılıç; Dilek Solmaz; Berrin Akın; Salim Dönmez; İsmail Sarı; Paul J. Leo; Tony J. Kenna; Fatos Önen; Mahdi Mahmoudi; Matthew A. Brown; Nurullah Akkoc

doi:10.1371/journal.pgen.1008038

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Open Access

Peer-reviewed

Research Article

Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis

Zhixiu Li,

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia
⨯
Servet Akar,

Roles Data curation, Investigation

Affiliation Department of Internal Medicine, Division of Rheumatology, Izmir Katip Çelebi University School of Medicine, İzmir, Turkey
⨯
Handan Yarkan,

Roles Data curation, Project administration

Affiliation Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey
⨯
Sau Kuen Lee,

Roles Data curation, Formal analysis

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia
⨯
Pınar Çetin,

Roles Data curation, Investigation, Project administration

Affiliation Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey
⨯
Gerçek Can,

Roles Data curation, Investigation, Project administration

Affiliation Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey
⨯
Gökce Kenar,

Roles Data curation, Formal analysis, Project administration

Affiliation Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey

http://orcid.org/0000-0002-0485-1369

⨯
Fernur Çapa,

Roles Data curation, Investigation

Affiliation Department of Molecular Medicine, Dokuz Eylul University Health Sciences Institute, İzmir, Turkey
⨯
Omer Nuri Pamuk,

Roles Data curation, Investigation, Project administration

Affiliation Department of Internal Medicine, Division of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey
⨯
Yavuz Pehlivan,

Roles Data curation, Investigation, Project administration

Affiliation Department of Rheumatology, School of Medicine, Uludağ University, Bursa, Turkey
⨯
Katie Cremin,

Roles Data curation, Formal analysis

Affiliation The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
⨯
Erika De Guzman,

Roles Data curation, Formal analysis

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia

http://orcid.org/0000-0002-2953-1513

⨯
Jessica Harris,

Roles Data curation, Formal analysis

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia
⨯
Lawrie Wheeler,

Roles Data curation, Formal analysis

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia
⨯
Ahmadreza Jamshidi,

Roles Data curation, Investigation, Resources

Affiliation Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
⨯
Mahdi Vojdanian,

Roles Data curation, Formal analysis, Investigation

Affiliation Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
⨯
Elham Farhadi,

Roles Data curation, Formal analysis, Resources

Affiliation Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
⨯
Nooshin Ahmadzadeh,

Roles Data curation, Investigation

Affiliation Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
⨯
Zeynep Yüce,

Roles Data curation, Investigation

Affiliation Department of Molecular Medicine, Dokuz Eylul University Health Sciences Institute, İzmir, Turkey
⨯
Ediz Dalkılıç,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Rheumatology, School of Medicine, Uludağ University, Bursa, Turkey
⨯
Dilek Solmaz,

Roles Data curation, Formal analysis

Affiliation Department of Internal Medicine, Division of Rheumatology, Izmir Katip Çelebi University School of Medicine, İzmir, Turkey
⨯
Berrin Akın,

Roles Data curation, Formal analysis

Affiliation Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey
⨯
Salim Dönmez,

Roles Data curation, Formal analysis

Affiliation Department of Internal Medicine, Division of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey
⨯
İsmail Sarı,

Roles Data curation, Formal analysis

Affiliation Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey
⨯
Paul J. Leo,

Roles Formal analysis, Writing – review & editing

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia

http://orcid.org/0000-0001-8325-4134

⨯
Tony J. Kenna,

Roles Conceptualization, Formal analysis, Investigation

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia

http://orcid.org/0000-0001-6844-3463

⨯
Fatos Önen,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey
⨯
Mahdi Mahmoudi,

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliation Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
⨯
Matthew A. Brown ,

Roles Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: matt.brown@qut.edu.au

Affiliation Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia
⨯
[ ... ],
Nurullah Akkoc

Roles Conceptualization, Formal analysis, Investigation, Resources

Affiliation Department of Internal Medicine, Division of Rheumatology, Celal Bayar University, Manisa, Turkey

http://orcid.org/0000-0002-3718-171X

⨯
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Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis

Zhixiu Li,
Servet Akar,
Handan Yarkan,
Sau Kuen Lee,
Pınar Çetin,
Gerçek Can,
Gökce Kenar,
Fernur Çapa,
Omer Nuri Pamuk,
Yavuz Pehlivan

Published: April 4, 2019
https://doi.org/10.1371/journal.pgen.1008038

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Ankylosing spondylitis
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Genetic loci
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Single nucleotide polymorphisms
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Linkage disequilibrium
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Variant genotypes
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Alleles
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Principal component analysis
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Genome-wide association studies
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