Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci

• Jiafen Gong ,

  Contributed equally to this work with: Jiafen Gong, Fan Wang, Bowei Xiao

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada

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• Fan Wang ,

  Contributed equally to this work with: Jiafen Gong, Fan Wang, Bowei Xiao

  Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada, Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada

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• Bowei Xiao ,

  Contributed equally to this work with: Jiafen Gong, Fan Wang, Bowei Xiao

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada

  ⨯
• Naim Panjwani,

  Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada

  http://orcid.org/0000-0001-7551-0759

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• Fan Lin,

  Roles Data curation, Writing – review & editing

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada

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• Katherine Keenan,

  Roles Data curation, Writing – review & editing

  Affiliation Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada

  ⨯
• Julie Avolio,

  Roles Data curation

  Affiliation Program in Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada

  http://orcid.org/0000-0003-0270-3941

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• Mohsen Esmaeili,

  Roles Visualization, Writing – original draft, Writing – review & editing

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada

  ⨯
• Lin Zhang,

  Roles Formal analysis, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada, Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada

  ⨯
• Gengming He,

  Roles Formal analysis, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada, Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

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• David Soave,

  Roles Formal analysis, Writing – review & editing

  Affiliations Wilfrid Laurier University, Department of Mathematics, Waterloo, Ontario, Canada, Ontario Institute for Cancer Research, Department of Computational Biology, Toronto, Ontario, Canada

  http://orcid.org/0000-0002-1325-7417

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• Scott Mastromatteo,

  Roles Formal analysis, Writing – review & editing

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada

  http://orcid.org/0000-0002-3551-2247

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• Zeynep Baskurt,

  Roles Writing – review & editing

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada

  ⨯
• Sangook Kim,

  Roles Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada, Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

  ⨯
• Wanda K. O’Neal,

  Roles Data curation, Writing – review & editing

  Affiliation Marsico Lung Institute and Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

  ⨯
• Deepika Polineni,

  Roles Data curation, Writing – review & editing

  Affiliations Marsico Lung Institute and Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Internal Medicine, University of Kansas Medical Centre, Kansas City, Kansas, United States of America

  http://orcid.org/0000-0001-8551-3734

  ⨯
• Scott M. Blackman,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Harriet Corvol,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliations Assistance Publique-Hôpitaux de Paris (AP-HP), Hôspital Trousseau, Pediatric Pulmonary Department; Institut National de la Santé et la Recherche Médicale (INSERM) U938, Paris, France, Sorbonne Universités, Université Pierre et Marie (UPMC) Paris, Paris, France

  ⨯
• Garry R. Cutting,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliations Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Mitchell Drumm,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliations Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Michael R. Knowles,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliation Marsico Lung Institute and Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

  http://orcid.org/0000-0002-4672-5969

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• Johanna M. Rommens,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

  http://orcid.org/0000-0001-8732-825X

  ⨯
• Lei Sun ,

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: sun@utstat.toronto.edu (LS); lisa.strug@utoronto.ca (LJS)

  Affiliations Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada, Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

  http://orcid.org/0000-0002-5640-937X

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•  [ ... ],
• Lisa J. Strug

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: sun@utstat.toronto.edu (LS); lisa.strug@utoronto.ca (LJS)

  Affiliations Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada, Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada, Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada

  http://orcid.org/0000-0003-0503-9740

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