Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment

• Lina Ding ,

  Contributed equally to this work with: Lina Ding, Lauren B. Shunkwiler

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Lauren B. Shunkwiler ,

  Contributed equally to this work with: Lina Ding, Lauren B. Shunkwiler

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

  http://orcid.org/0000-0003-2632-7610

  ⨯
• Nicholas W. Harper,

  Roles Formal analysis, Software, Writing – review & editing

  Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-4037-7473

  ⨯
• Yang Zhao,

  Roles Conceptualization, Investigation, Methodology

  Current address: Pfizer Inc., Cambridge, Massachusetts, United States of America.

  Affiliation Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

  http://orcid.org/0000-0002-4303-1240

  ⨯
• Kunihiko Hinohara,

  Roles Investigation, Methodology

  Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Sung Jin Huh,

  Roles Investigation, Methodology

  Current address: ImmunoGen, Inc., Waltham, Massachusetts, United States of America.

  Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Muhammad B. Ekram,

  Roles Formal analysis, Software

  Current address: WuXi NextCODE, Cambridge, Massachusetts, United States of America.

  Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0001-5555-6872

  ⨯
• Jan Guz,

  Roles Investigation, Methodology

  Affiliation Department of Regenerative Medicine and Cell Biology, Transgenic and Gene Function Core, Medical University of South Carolina, Charleston, South Carolina, United States of America

  ⨯
• Michael J. Kern,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Regenerative Medicine and Cell Biology, Transgenic and Gene Function Core, Medical University of South Carolina, Charleston, South Carolina, United States of America

  ⨯
• Alexander Awgulewitsch,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Medicine, Transgenic and Gene Function Core, Medical University of South Carolina, Charleston, South Carolina, United States of America

  ⨯
• James D. Shull,

  Roles Resources, Writing – review & editing

  Affiliation Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0003-4537-5159

  ⨯
• Bart M. G. Smits ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: bmgsmits@hotmail.com (BMGS); kornelia_polyak@dfci.harvard.edu (KP)

  Affiliation Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

  http://orcid.org/0000-0003-3806-2357

  ⨯
• Kornelia Polyak

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: bmgsmits@hotmail.com (BMGS); kornelia_polyak@dfci.harvard.edu (KP)

  Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-5964-0382

  ⨯