TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Peng Wang; Jianwen Deng; Jie Dong; Jianghong Liu; Eileen H. Bigio; Marsel Mesulam; Tao Wang; Lei Sun; Li Wang; Alan Yueh-Luen Lee; Warren A. McGee; Xiaoping Chen; Kazuo Fushimi; Li Zhu; Jane Y. Wu

doi:10.1371/journal.pgen.1007947

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Open Access

Peer-reviewed

Research Article

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Peng Wang ,

Contributed equally to this work with: Peng Wang, Jianwen Deng

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

Affiliations State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Jianwen Deng ,

Contributed equally to this work with: Peng Wang, Jianwen Deng

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

Current address: Department of Neurology, Peking University First Affiliated Hospital, Beijing, China

Affiliation State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
⨯
Jie Dong,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration

Affiliation State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
⨯
Jianghong Liu,

Roles Project administration, Resources

Affiliation State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
⨯
Eileen H. Bigio,

Roles Resources

Affiliation Department of Pathology & Neurology, The Cognitive Neurology & Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Marsel Mesulam,

Roles Resources

Affiliation Department of Pathology & Neurology, The Cognitive Neurology & Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Tao Wang,

Roles Conceptualization, Funding acquisition, Methodology

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Lei Sun,

Roles Methodology

Affiliation Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
⨯
Li Wang,

Roles Methodology

Affiliation Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
⨯
Alan Yueh-Luen Lee,

Roles Resources

Affiliation National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
⨯
Warren A. McGee,

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Xiaoping Chen,

Roles Methodology

Affiliation Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Kazuo Fushimi,

Roles Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Li Zhu ,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: zhuli@moon.ibp.ac.cn (LZ); jane-wu@northwestern.edu (JYW)

Affiliations State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Jane Y. Wu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: zhuli@moon.ibp.ac.cn (LZ); jane-wu@northwestern.edu (JYW)

Affiliations State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

http://orcid.org/0000-0003-1794-1213

⨯

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Peng Wang,
Jianwen Deng,
Jie Dong,
Jianghong Liu,
Eileen H. Bigio,
Marsel Mesulam,
Tao Wang,
Lei Sun,
Li Wang,
Alan Yueh-Luen Lee

Published: May 17, 2019
https://doi.org/10.1371/journal.pgen.1007947

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