Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation

• Andrea Callegari ,

  Contributed equally to this work with: Andrea Callegari, Christian Sieben

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Current address: EMBL Heidelberg, Germany

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• Christian Sieben ,

  Contributed equally to this work with: Andrea Callegari, Christian Sieben

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Swiss National Centre for Competence in Research (NCCR) in Chemical Biology

  http://orcid.org/0000-0002-2836-2623

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• Alexander Benke,

  Roles Conceptualization, Methodology, Validation, Writing – review & editing

  Affiliation Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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• David M. Suter,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation UPSUTER, The Institute of Bioengineering (IBI), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

  http://orcid.org/0000-0001-5644-4899

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• Beat Fierz,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Swiss National Centre for Competence in Research (NCCR) in Chemical Biology, Institute of Chemical Sciences and Engineering (ISIC), School of Basic Science, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

  http://orcid.org/0000-0002-2991-3044

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• Davide Mazza,

  Roles Formal analysis, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliations Fondazione CEN, European Center for Nanomedicine Milano, Italy, Experimental Imaging Center, IRCCS San Raffaele Scientific Institute Milano, Italy

  http://orcid.org/0000-0003-2776-4142

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• Suliana Manley

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: suliana.manley@epfl.ch

  Affiliations Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, UPSUTER, The Institute of Bioengineering (IBI), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

  http://orcid.org/0000-0002-4755-4778

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