GRAM: A GeneRAlized Model to predict the molecular effect of a non-coding variant in a cell-type specific manner

• Shaoke Lou,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0002-2626-5897

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• Kellie A. Cotter ,

  Contributed equally to this work with: Kellie A. Cotter, Tianxiao Li, Jin Liang

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Department for BioMedical Research, University of Bern, CH, Bern, Switzerland

  http://orcid.org/0000-0002-2574-815X

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• Tianxiao Li ,

  Contributed equally to this work with: Kellie A. Cotter, Tianxiao Li, Jin Liang

  Roles Formal analysis, Resources, Writing – original draft, Writing – review & editing

  Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0002-9147-7511

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• Jin Liang ,

  Contributed equally to this work with: Kellie A. Cotter, Tianxiao Li, Jin Liang

  Roles Validation, Writing – review & editing

  Affiliation Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, United States of America

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• Hussein Mohsen,

  Roles Formal analysis, Writing – original draft

  Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in the History of Science and Medicine, Yale University, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0002-6263-8865

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• Jason Liu,

  Roles Visualization, Writing – review & editing

  Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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• Jing Zhang,

  Roles Visualization

  Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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• Sandra Cohen,

  Roles Validation

  Affiliation Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, New York, United States of America

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• Jinrui Xu,

  Roles Data curation, Writing – review & editing

  Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0003-1944-2821

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• Haiyuan Yu,

  Roles Conceptualization, Funding acquisition

  Affiliations Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, United States of America, Department of Computational Biology, Cornell University, Ithaca, New York, United States of America

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• Mark A. Rubin,

  Roles Conceptualization, Funding acquisition

  Affiliations Department for BioMedical Research, University of Bern, CH, Bern, Switzerland, Weill Cornell Medicine, New York, United States of America

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• Mark Gerstein

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: mark@gersteinlab.org

  Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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