The yeast stress inducible Ssa Hsp70 reduces α-synuclein toxicity by promoting its degradation through autophagy

Arpit Gupta; Anuradhika Puri; Prashant Singh; Surabhi Sonam; Richa Pandey; Deepak Sharma

doi:10.1371/journal.pgen.1007751

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Open Access

Peer-reviewed

Research Article

The yeast stress inducible Ssa Hsp70 reduces α-synuclein toxicity by promoting its degradation through autophagy

Arpit Gupta,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation G. N. Ramachandran Protein Centre, Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India
⨯
Anuradhika Puri,

Roles Investigation, Methodology, Validation, Visualization

Affiliation G. N. Ramachandran Protein Centre, Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India
⨯
Prashant Singh,

Roles Investigation, Methodology, Validation, Visualization

Affiliation G. N. Ramachandran Protein Centre, Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India
⨯
Surabhi Sonam,

Roles Investigation, Methodology, Validation, Visualization

Affiliation G. N. Ramachandran Protein Centre, Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India

http://orcid.org/0000-0003-3922-731X

⨯
Richa Pandey,

Roles Investigation, Methodology, Validation, Visualization

Affiliation G. N. Ramachandran Protein Centre, Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India
⨯
Deepak Sharma

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: deepaks@imtech.res.in

Affiliation G. N. Ramachandran Protein Centre, Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India

http://orcid.org/0000-0003-1104-575X

⨯

The yeast stress inducible Ssa Hsp70 reduces α-synuclein toxicity by promoting its degradation through autophagy

Arpit Gupta,
Anuradhika Puri,
Prashant Singh,
Surabhi Sonam,
Richa Pandey,
Deepak Sharma

Published: October 30, 2018
https://doi.org/10.1371/journal.pgen.1007751

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Toxicity
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Autophagic cell death
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Yeast
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