Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

• Elaine Pirie ,

  Contributed equally to this work with: Elaine Pirie, Shayoni Ray

  Roles Data curation, Formal analysis, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

  Affiliation Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America

  http://orcid.org/0000-0002-1992-9106

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• Shayoni Ray ,

  Contributed equally to this work with: Elaine Pirie, Shayoni Ray

  Roles Data curation, Investigation, Writing – original draft

  Current address: Radiation Biophysics and Cancer Genomics, Space Biology Research Branch, NASA Ames Research Center, Moffett Field, California, United States of America

  Affiliation Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America

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• Calvin Pan,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-0752-833X

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• Wuxia Fu,

  Roles Data curation

  Affiliation Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America

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• Andrew F. Powers,

  Roles Data curation

  Affiliation Exploratory Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America

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• Danielle Polikoff,

  Roles Data curation

  Affiliation Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America

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• Colton M. Miller,

  Roles Data curation

  Affiliation Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States of America

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• Katrina M. Kudrna,

  Roles Data curation

  Affiliation Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States of America

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• Edward N. Harris,

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States of America

  http://orcid.org/0000-0001-7045-1040

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• Aldons J. Lusis,

  Roles Formal analysis, Investigation

  Affiliation Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America

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• Rosanne M. Crooke,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America

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• Richard G. Lee

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: RLee@ionisph.com

  Affiliation Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America

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