De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay

• Susan M. Hiatt ,

  Contributed equally to this work with: Susan M. Hiatt, Matthew B. Neu

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America

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• Matthew B. Neu ,

  Contributed equally to this work with: Susan M. Hiatt, Matthew B. Neu

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States of America

  http://orcid.org/0000-0003-0808-6921

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• Ryne C. Ramaker,

  Roles Investigation

  Affiliations HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States of America

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• Andrew A. Hardigan,

  Roles Investigation

  Affiliations HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States of America

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• Jeremy W. Prokop,

  Roles Investigation, Software

  Affiliation Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI, United States of America

  http://orcid.org/0000-0002-1818-9695

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• Miroslava Hancarova,

  Roles Investigation

  Affiliation Department of Biology and Medical Genetics, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

  http://orcid.org/0000-0001-6772-8862

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• Darina Prchalova,

  Roles Investigation

  Affiliation Department of Biology and Medical Genetics, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

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• Marketa Havlovicova,

  Roles Investigation

  Affiliation Department of Biology and Medical Genetics, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

  ⨯
• Jan Prchal,

  Roles Investigation, Software

  Affiliation Laboratory of NMR Spectroscopy, University of Chemistry and Technology, Prague, Czech Republic

  ⨯
• Viktor Stranecky,

  Roles Data curation, Software

  Affiliation Department of Pediatrics and Adolescent Medicine, Diagnostic and Research Unit for Rare Diseases, Charles University 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic

  http://orcid.org/0000-0002-2599-6479

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• Dwight K. C. Yim,

  Roles Investigation

  Affiliation Kaiser Permanente-Hawaii, Honolulu, HI, United States of America

  ⨯
• Zöe Powis,

  Roles Investigation

  Affiliation Department of Emerging Genetic Medicine, Ambry Genetics, Aliso Viejo, CA, United States of America

  http://orcid.org/0000-0002-1347-4358

  ⨯
• Boris Keren,

  Roles Investigation

  Affiliation Department of Genetics, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

  http://orcid.org/0000-0001-6172-8247

  ⨯
• Caroline Nava,

  Roles Investigation

  Affiliation Department of Genetics, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

  http://orcid.org/0000-0003-1272-0518

  ⨯
• Cyril Mignot,

  Roles Investigation

  Affiliations Department of Genetics, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France, Centre de Référence Déficiences Intellectuelles de Causes Rares, Paris, France, Groupe de Recherche Clinique UPMC "Déficience Intellectuelle et Autisme", Paris, France

  http://orcid.org/0000-0002-3462-3463

  ⨯
• Marlene Rio,

  Roles Investigation

  Affiliations Centre de Référence Déficiences Intellectuelles de Causes Rares, Paris, France, Assistance Publique-Hôpitaux de Paris, service de Génétique, Hôpital Necker-Enfants-Malades, Paris, France

  http://orcid.org/0000-0003-2049-5058

  ⨯
• Anya Revah-Politi,

  Roles Investigation

  Affiliation Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, United States of America

  ⨯
• Parisa Hemati,

  Roles Investigation

  Affiliation Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, United States of America

  http://orcid.org/0000-0001-6347-552X

  ⨯
• Nicholas Stong,

  Roles Investigation

  Affiliation Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, United States of America

  http://orcid.org/0000-0002-0678-637X

  ⨯
• Alejandro D. Iglesias,

  Roles Investigation

  Affiliation Division of Clinical Genetics, Department of Pediatrics, Columbia University Medical Center, New York, NY, United States of America

  ⨯
• Sharon F. Suchy,

  Roles Investigation

  Affiliation GeneDx, Gaithersburg, MD, United States of America

  ⨯
• Rebecca Willaert,

  Roles Investigation

  Affiliation GeneDx, Gaithersburg, MD, United States of America

  ⨯
• Ingrid M. Wentzensen,

  Roles Investigation

  Affiliation GeneDx, Gaithersburg, MD, United States of America

  ⨯
• Patricia G. Wheeler,

  Roles Investigation

  Affiliation Arnold Palmer Hospital, Division of Genetics, Orlando, FL, United States of America

  ⨯
• Lauren Brick,

  Roles Investigation

  Affiliation Department of Genetics, McMaster Children's Hospital, Hamilton, Ontario, Canada

  http://orcid.org/0000-0001-5586-0284

  ⨯
• Mariya Kozenko,

  Roles Investigation

  Affiliation Department of Genetics, McMaster Children's Hospital, Hamilton, Ontario, Canada

  ⨯
• Anna C. E. Hurst,

  Roles Investigation

  Affiliation Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States of America

  http://orcid.org/0000-0002-9765-9703

  ⨯
• James W. Wheless,

  Roles Investigation

  Affiliations Division of Pediatric Neurology, University of Tennessee Health Science Center, Neuroscience Institute & Le Bonheur Comprehensive Epilepsy Program, Memphis, TN, United States of America, Le Bonheur Children’s Hospital, Memphis, TN, United States of America

  ⨯
• Yves Lacassie,

  Roles Investigation

  Affiliations Division of Clinical Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States of America, Department of Genetics, Children's Hospital, New Orleans, LA, United States of America

  ⨯
• Richard M. Myers,

  Roles Funding acquisition, Supervision

  Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America

  ⨯
• Gregory S. Barsh,

  Roles Writing – review & editing

  Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America

  http://orcid.org/0000-0002-0838-1042

  ⨯
• Zdenek Sedlacek,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Biology and Medical Genetics, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

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•  [ ... ],
• Gregory M. Cooper

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Visualization, Writing – review & editing

  * E-mail: gcooper@hudsonalpha.org

  Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America

  http://orcid.org/0000-0001-5509-9923

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