Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme

• JohnCarlo Kristofich,

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

  Current address: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

  Affiliations Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America, Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, United States of America

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• Andrew B. Morgenthaler,

  Roles Formal analysis, Investigation

  Affiliations Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America, Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, United States of America

  http://orcid.org/0000-0003-3822-0212

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• Wallis R. Kinney,

  Roles Investigation

  Affiliations Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America, Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, United States of America

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• Christopher C. Ebmeier,

  Roles Formal analysis, Investigation

  Affiliation Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America

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• Daniel J. Snyder,

  Roles Investigation

  Affiliation University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America

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• William M. Old,

  Roles Supervision

  Affiliation Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America

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• Vaughn S. Cooper,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0001-7726-0765

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• Shelley D. Copley

  Roles Conceptualization, Formal analysis, Funding acquisition, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: shelley.copley@colorado.edu

  Affiliations Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America, Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, United States of America

  http://orcid.org/0000-0001-9727-7919

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