The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer

• Jennifer K. Pleiman,

  Roles Conceptualization, Formal analysis, Investigation, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliations McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Laboratory of Genetics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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• Amy A. Irving,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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• Zhishi Wang,

  Roles Software

  Affiliation Department of Statistics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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• Erik Toraason,

  Roles Investigation, Writing – review & editing

  Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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• Linda Clipson,

  Roles Data curation, Formal analysis, Visualization, Writing – original draft

  Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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• William F. Dove ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: dove@oncology.wisc.edu (WFD); ddeming@medicine.wisc.edu (DAD); newton@biostat.wisc.edu (MAN)

  Affiliations McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Laboratory of Genetics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0002-8666-6895

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• Dustin A. Deming ,

  Roles Funding acquisition, Validation, Writing – review & editing

  * E-mail: dove@oncology.wisc.edu (WFD); ddeming@medicine.wisc.edu (DAD); newton@biostat.wisc.edu (MAN)

  Affiliations McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Carbone Cancer Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Division of Hematology and Medical Oncology, Department of Medicine, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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• Michael A. Newton

  Roles Formal analysis, Funding acquisition, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: dove@oncology.wisc.edu (WFD); ddeming@medicine.wisc.edu (DAD); newton@biostat.wisc.edu (MAN)

  Affiliations Department of Statistics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Carbone Cancer Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Department of Biostatistics and Medical Informatics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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