Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility

• Asaf Ta-Shma ,

  Contributed equally to this work with: Asaf Ta-Shma, Rim Hjeij

  Roles Conceptualization, Data curation, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Pediatric Cardiology, Hadassah, Hebrew University Medical Center, Jerusalem, Israel, Monique and Jacques Roboh Department of Genetic Research, Hadassah, Hebrew University Medical Center, Jerusalem, Israel

  http://orcid.org/0000-0003-0076-9568

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• Rim Hjeij ,

  Contributed equally to this work with: Asaf Ta-Shma, Rim Hjeij

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

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• Zeev Perles,

  Roles Resources

  Affiliation Department of Pediatric Cardiology, Hadassah, Hebrew University Medical Center, Jerusalem, Israel

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• Gerard W. Dougherty,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

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• Ibrahim Abu Zahira,

  Roles Resources

  Affiliation Department of Pediatric Cardiology, Hadassah, Hebrew University Medical Center, Jerusalem, Israel

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• Stef J. F. Letteboer,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands

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• Dinu Antony,

  Roles Formal analysis, Investigation, Validation

  Affiliations Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands, Pediatric Genetics Division, Center for Pediatrics and Adolescent Medicine, Faculty of Medicine, Freiburg University, Freiburg, Germany

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• Alaa Darwish,

  Roles Resources

  Affiliation Department of Pediatric Cardiology, Hadassah, Hebrew University Medical Center, Jerusalem, Israel

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• Dorus A. Mans,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands

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• Sabrina Spittler,

  Roles Investigation

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  ⨯
• Christine Edelbusch,

  Roles Investigation

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  ⨯
• Sandra Cindrić,

  Roles Investigation

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  http://orcid.org/0000-0002-8303-100X

  ⨯
• Tabea Nöthe-Menchen,

  Roles Investigation

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  ⨯
• Heike Olbrich,

  Roles Formal analysis

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  ⨯
• Friederike Stuhlmann,

  Roles Investigation

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  ⨯
• Isabella Aprea,

  Roles Investigation

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  ⨯
• Petra Pennekamp,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  ⨯
• Niki T. Loges,

  Roles Formal analysis

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

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• Oded Breuer,

  Roles Resources

  Affiliation Pediatric Pulmonology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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• Avraham Shaag,

  Roles Resources

  Affiliation Monique and Jacques Roboh Department of Genetic Research, Hadassah, Hebrew University Medical Center, Jerusalem, Israel

  ⨯
• Azaria J. J. T. Rein,

  Roles Resources

  Affiliation Department of Pediatric Cardiology, Hadassah, Hebrew University Medical Center, Jerusalem, Israel

  ⨯
• Elif Yilmaz Gulec,

  Roles Resources

  Affiliation University of Health Sciences, Kanuni Sultan Suleyman, Training and Research Hospital, Department of Medical Genetics, Istanbul, Turkey

  ⨯
• Alper Gezdirici,

  Roles Resources

  Affiliation University of Health Sciences, Kanuni Sultan Suleyman, Training and Research Hospital, Department of Medical Genetics, Istanbul, Turkey

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• Revital Abitbul,

  Roles Resources

  Affiliation Pediatric Department, Ziv Medical Center, Faculty of Medicine, Bar Ilan University, Safed, Israel

  ⨯
• Nael Elias,

  Roles Resources

  Affiliation Saint Vincent Hospital, Nazareth, Faculty of Medicine, Bar Ilan University, Israel

  ⨯
• Israel Amirav,

  Roles Resources

  Affiliations Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada, Pediatric Pulmonology Unit, Tel Aviv Medical Center, Tel Aviv, Israel

  http://orcid.org/0000-0002-6917-5285

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• Miriam Schmidts,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliations Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands, Pediatric Genetics Division, Center for Pediatrics and Adolescent Medicine, Faculty of Medicine, Freiburg University, Freiburg, Germany

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• Ronald Roepman,

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Validation

  Affiliations Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands

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• Orly Elpeleg,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Monique and Jacques Roboh Department of Genetic Research, Hadassah, Hebrew University Medical Center, Jerusalem, Israel

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•  [ ... ],
• Heymut Omran

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: heymut.omran@ukmuenster.de

  Affiliation Department of General Pediatrics, University Hospital Muenster, Muenster, Germany

  http://orcid.org/0000-0003-0282-6765

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