Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling

Olivia F. Duncan; Lucy Granat; Ramya Ranganathan; Vandana K. Singh; David Mazaud; Manolis Fanto; David Chambers; Clive G. Ballard; Joseph M. Bateman

doi:10.1371/journal.pgen.1007567

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Open Access

Peer-reviewed

Research Article

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling

Olivia F. Duncan ,

Contributed equally to this work with: Olivia F. Duncan, Lucy Granat

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, United Kingdom
⨯
Lucy Granat ,

Contributed equally to this work with: Olivia F. Duncan, Lucy Granat

Roles Data curation, Formal analysis, Investigation

Affiliation Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, United Kingdom
⨯
Ramya Ranganathan,

Roles Formal analysis

Affiliation Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, United Kingdom
⨯
Vandana K. Singh,

Roles Data curation, Investigation

Affiliation Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, United Kingdom
⨯
David Mazaud,

Roles Investigation

Affiliation Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, United Kingdom

http://orcid.org/0000-0003-3998-9330

⨯
Manolis Fanto,

Roles Funding acquisition, Supervision

Affiliation Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, United Kingdom

http://orcid.org/0000-0001-7807-2563

⨯
David Chambers,

Roles Data curation, Investigation

Affiliation Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom
⨯
Clive G. Ballard,

Roles Funding acquisition, Supervision

Affiliation Medical School Building, St Luke's Campus, University of Exeter, Exeter, United Kingdom

http://orcid.org/0000-0003-0022-5632

⨯
Joseph M. Bateman

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: joseph_matthew.bateman@kcl.ac.uk

Affiliation Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, United Kingdom

http://orcid.org/0000-0003-0754-1785

⨯

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling

Olivia F. Duncan,
Lucy Granat,
Ramya Ranganathan,
Vandana K. Singh,
David Mazaud,
Manolis Fanto,
David Chambers,
Clive G. Ballard,
Joseph M. Bateman

Published: July 30, 2018
https://doi.org/10.1371/journal.pgen.1007567

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