Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans

Yang Zhou; Yan Qin; Yingying Qin; Binyang Xu; Ting Guo; Hanni Ke; Min Chen; Lianjun Zhang; Feng Han; Yaqiong Li; Min Chen; Axel Behrens; Yaqing Wang; Zhiheng Xu; Zi-Jiang Chen; Fei Gao

doi:10.1371/journal.pgen.1007463

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Open Access

Peer-reviewed

Research Article

Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans

Yang Zhou ,

Contributed equally to this work with: Yang Zhou, Yan Qin, Yingying Qin

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Yan Qin ,

Contributed equally to this work with: Yang Zhou, Yan Qin, Yingying Qin

Roles Methodology

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Yingying Qin ,

Contributed equally to this work with: Yang Zhou, Yan Qin, Yingying Qin

Roles Methodology, Resources

Affiliation Center for Reproductive Medicine of Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China
⨯
Binyang Xu,

Roles Investigation

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Ting Guo,

Roles Methodology

Affiliation Center for Reproductive Medicine of Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China
⨯
Hanni Ke,

Roles Methodology

Affiliation Center for Reproductive Medicine of Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China
⨯
Min Chen,

Roles Formal analysis

Affiliation State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
⨯
Lianjun Zhang,

Roles Methodology

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Feng Han,

Roles Methodology

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Yaqiong Li,

Roles Methodology

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Min Chen,

Roles Methodology

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Axel Behrens,

Roles Resources

Affiliation CR-UK London Research Institute, London, United Kingdom
⨯
Yaqing Wang,

Roles Methodology, Resources

Affiliation State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Zhiheng Xu ,

Roles Methodology, Resources

* E-mail: zhihengxu1966@163.com (ZX); chenzijiang@hotmail.com (ZJC); gaof@ioz.ac.cn (FG)

Affiliation State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Zi-Jiang Chen ,

Roles Methodology, Resources

* E-mail: zhihengxu1966@163.com (ZX); chenzijiang@hotmail.com (ZJC); gaof@ioz.ac.cn (FG)

Affiliation Center for Reproductive Medicine of Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China
⨯
[ ... ],
Fei Gao

Roles Funding acquisition, Project administration, Writing – review & editing

* E-mail: zhihengxu1966@163.com (ZX); chenzijiang@hotmail.com (ZJC); gaof@ioz.ac.cn (FG)

Affiliations State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China

http://orcid.org/0000-0002-4029-6411

⨯
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Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans

Yang Zhou,
Yan Qin,
Yingying Qin,
Binyang Xu,
Ting Guo,
Hanni Ke,
Min Chen,
Lianjun Zhang,
Feng Han,
Yaqiong Li

Published: August 13, 2018
https://doi.org/10.1371/journal.pgen.1007463

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