Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

• Johanna M. Huusko ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: johanna.huusko@oulu.fi (JMH); Louis.Muglia@cchmc.org (LJM)

  Affiliations PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland, Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States of America

  http://orcid.org/0000-0001-8663-9005

  ⨯
• Minna K. Karjalainen,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland

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• Britney E. Graham,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Ge Zhang,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States of America

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• Emily G. Farrow,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri, United States of America

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• Neil A. Miller,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri, United States of America

  http://orcid.org/0000-0002-6151-4780

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• Bo Jacobsson,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway

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• Haley R. Eidem,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America

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• Jeffrey C. Murray,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

  http://orcid.org/0000-0001-6346-6551

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• Bruce Bedell,

  Roles Resources

  Affiliation Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

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• Patrick Breheny,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Biostatistics, University of Iowa, Iowa City, Iowa, United States of America

  http://orcid.org/0000-0002-0650-1119

  ⨯
• Noah W. Brown,

  Roles Data curation, Formal analysis

  Affiliation Department of Epidemiology, College of Public Health and Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

  ⨯
• Frans L. Bødker,

  Roles Data curation

  Affiliation Institute of Public Health, University of Southern Denmark, Odense, Denmark

  ⨯
• Nadia K. Litterman,

  Roles Data curation, Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliation 23andMe, Inc. Mountain View, California, United States of America

  http://orcid.org/0000-0002-2734-8010

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• Pan-Pan Jiang,

  Roles Data curation, Formal analysis, Investigation, Resources

  Affiliation 23andMe, Inc. Mountain View, California, United States of America

  ⨯
• Laura Russell,

  Roles Data curation, Formal analysis, Investigation, Resources

  Affiliation 23andMe, Inc. Mountain View, California, United States of America

  ⨯
• David A. Hinds,

  Roles Data curation, Formal analysis, Investigation, Resources

  Affiliation 23andMe, Inc. Mountain View, California, United States of America

  http://orcid.org/0000-0002-4911-803X

  ⨯
• Youna Hu,

  Roles Data curation, Formal analysis, Investigation, Resources

  Affiliation 23andMe, Inc. Mountain View, California, United States of America

  ⨯
• the 23andMe Research Team ,

  ¶¶ Membership of the 23andMe Research Team is provided in the Acknowledgments.

  Affiliation 23andMe, Inc. Mountain View, California, United States of America

  ⨯
• Antonis Rokas,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America

  http://orcid.org/0000-0002-7248-6551

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• Kari Teramo,

  Roles Resources, Writing – review & editing

  Affiliation Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

  ⨯
• Kaare Christensen,

  Roles Resources, Writing – review & editing

  Affiliation Institute of Public Health, University of Southern Denmark, Odense, Denmark

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• Scott M. Williams,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  http://orcid.org/0000-0002-4835-9544

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• Mika Rämet,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland

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• Stephen F. Kingsmore,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Rady Children’s Institute for Genomic Medicine, Rady Children's Hospital, San Diego, California, United States of America

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• Kelli K. Ryckman ,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  ¶^‡ These authors are joint senior authors on this work.

  Affiliation Department of Epidemiology, College of Public Health and Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

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• Mikko Hallman ,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  ¶^‡ These authors are joint senior authors on this work.

  Affiliation PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland

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•  [ ... ],
• Louis J. Muglia

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: johanna.huusko@oulu.fi (JMH); Louis.Muglia@cchmc.org (LJM)

  ¶^‡ These authors are joint senior authors on this work.

  Affiliation Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States of America

  http://orcid.org/0000-0002-0301-8770

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