Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage

• Agnese Collino ,

  Contributed equally to this work with: Agnese Collino, Alberto Termanini

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Department of Experimental Oncology, European Institute of Oncology (IEO), Milan, Italy

  ⨯
• Alberto Termanini ,

  Contributed equally to this work with: Agnese Collino, Alberto Termanini

  Roles Conceptualization, Data curation, Formal analysis, Software, Visualization

  Affiliation Humanitas Clinical and Research Center, Rozzano, Milan, Italy

  http://orcid.org/0000-0002-9697-906X

  ⨯
• Paola Nicoli,

  Roles Investigation, Methodology

  Affiliation Department of Experimental Oncology, European Institute of Oncology (IEO), Milan, Italy

  ⨯
• Giuseppe Diaferia,

  Roles Investigation, Methodology

  Current address: Humanitas University, Pieve Emanuele, Milan, Italy

  Affiliation Department of Experimental Oncology, European Institute of Oncology (IEO), Milan, Italy

  http://orcid.org/0000-0003-4022-8483

  ⨯
• Sara Polletti,

  Roles Investigation, Methodology

  Affiliation Humanitas University, Pieve Emanuele, Milan, Italy

  http://orcid.org/0000-0002-5433-0502

  ⨯
• Camilla Recordati,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation Mouse & Animal Pathology Laboratory, Fondazione Filarete, Milan, Italy

  ⨯
• Vittoria Castiglioni,

  Roles Investigation, Methodology, Validation

  Affiliation Mouse & Animal Pathology Laboratory, Fondazione Filarete, Milan, Italy

  ⨯
• Donatella Caruso,

  Roles Methodology

  Affiliation DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy

  ⨯
• Nico Mitro ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: nico.mitro@unimi.it (NM); gioacchino.natoli@hunimed.eu (GN); serena.ghisletti@humanitasresearch.it (SG)

  ¶‡ NM, GN, and SG also contributed equally to this work.

  Affiliation DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy

  http://orcid.org/0000-0002-5000-3619

  ⨯
• Gioacchino Natoli ,

  Roles Conceptualization, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: nico.mitro@unimi.it (NM); gioacchino.natoli@hunimed.eu (GN); serena.ghisletti@humanitasresearch.it (SG)

  ¶‡ NM, GN, and SG also contributed equally to this work.

  Affiliations Humanitas Clinical and Research Center, Rozzano, Milan, Italy, Humanitas University, Pieve Emanuele, Milan, Italy

  ⨯
• Serena Ghisletti

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: nico.mitro@unimi.it (NM); gioacchino.natoli@hunimed.eu (GN); serena.ghisletti@humanitasresearch.it (SG)

  ¶‡ NM, GN, and SG also contributed equally to this work.

  Affiliation Humanitas Clinical and Research Center, Rozzano, Milan, Italy

  http://orcid.org/0000-0002-7087-5553

  ⨯