Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

• Manuel A. Rivas ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

  * E-mail: mrivas@stanford.edu (MAR); judy.cho@mssm.edu (JHC); Dermot.McGovern@cshs.org (DPBM); mjdaly@atgu.mgh.harvard.edu (MJD)

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Department of Biomedical Data Science, Stanford University, Stanford, CA, United States of America

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• Brandon E. Avila,

  Roles Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

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• Jukka Koskela,

  Roles Formal analysis, Validation, Visualization, Writing – review & editing

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

  ⨯
• Hailiang Huang,

  Roles Data curation, Formal analysis, Methodology, Visualization

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  http://orcid.org/0000-0003-1461-5762

  ⨯
• Christine Stevens,

  Roles Data curation, Project administration, Resources

  Affiliation Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America

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• Matti Pirinen,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland

  ⨯
• Talin Haritunians,

  Roles Resources

  Affiliation Translational Genomics Unit, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America

  http://orcid.org/0000-0002-9005-7750

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• Benjamin M. Neale,

  Roles Data curation, Resources

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

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• Mitja Kurki,

  Roles Data curation

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  http://orcid.org/0000-0002-6010-8617

  ⨯
• Andrea Ganna,

  Roles Data curation

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Daniel Graham,

  Roles Resources

  Affiliation Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America

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• Benjamin Glaser,

  Roles Resources

  Affiliation Hadassah-Hebrew University Medical Center, Endocrinology and Metabolism Service Department of Internal Medicine, Jerusalem, Israel

  ⨯
• Inga Peter,

  Roles Resources

  Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

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• Gil Atzmon,

  Roles Resources

  Affiliations Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY, United States of America, Faculty of Natural Sciences, University of Haifa, Haifa, Israel

  ⨯
• Nir Barzilai,

  Roles Resources

  Affiliation Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY, United States of America

  ⨯
• Adam P. Levine,

  Roles Resources

  Affiliation Division of Medicine, University College London, London, United Kingdom

  ⨯
• Elena Schiff,

  Roles Resources

  Affiliation Division of Medicine, University College London, London, United Kingdom

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• Nikolas Pontikos,

  Roles Resources

  Affiliations Division of Medicine, University College London, London, United Kingdom, UCL Genetics Institute, University College London, London, United Kingdom

  http://orcid.org/0000-0003-1782-4711

  ⨯
• Ben Weisburd,

  Roles Resources

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Monkol Lek,

  Roles Data curation, Formal analysis

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Konrad J. Karczewski,

  Roles Data curation, Resources

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  http://orcid.org/0000-0003-2878-4671

  ⨯
• Jonathan Bloom,

  Roles Software

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Eric V. Minikel,

  Roles Resources

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Britt-Sabina Petersen,

  Roles Resources

  Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany

  ⨯
• Laurent Beaugerie,

  Roles Resources

  Affiliation Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris, Paris, France

  ⨯
• Philippe Seksik,

  Roles Resources

  Affiliation Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris, Paris, France

  ⨯
• Jacques Cosnes,

  Roles Resources

  Affiliation Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris, Paris, France

  ⨯
• Stefan Schreiber,

  Roles Resources

  Affiliation Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany

  ⨯
• Bernd Bokemeyer,

  Roles Resources

  Affiliation Gastroenterology Practice, Minden, Germany

  ⨯
• Johannes Bethge,

  Roles Resources

  Affiliation Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany

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• International IBD Genetics Consortium ,

  ¶Consortium members listed in Acknowledgments section.

  ⨯
• NIDDK IBD Genetics Consortium ,

  ¶Consortium members listed in Acknowledgments section.

  ⨯
• T2D-GENES Consortium ,

  ¶Consortium members listed in Acknowledgments section.

  ⨯
• Graham Heap,

  Roles Resources

  Affiliation IBD Pharmacogenetics, Royal Devon and Exeter NHS Trust, Exeter, United Kingdom

  http://orcid.org/0000-0003-4131-6792

  ⨯
• Tariq Ahmad,

  Roles Resources

  Affiliation Peninsula College of Medicine and Dentistry, Exeter, United Kingdom

  ⨯
• Vincent Plagnol,

  Roles Resources

  Affiliation UCL Genetics Institute, University College London, London, United Kingdom

  ⨯
• Anthony W. Segal,

  Roles Resources

  Affiliation Division of Medicine, University College London, London, United Kingdom

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• Stephan Targan,

  Roles Resources

  Affiliation Translational Genomics Unit, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America

  ⨯
• Dan Turner,

  Roles Resources

  Affiliation Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel

  ⨯
• Paivi Saavalainen,

  Roles Resources

  Affiliation Research Programs Unit, Immunobiology, and Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland

  ⨯
• Martti Farkkila,

  Roles Resources

  Affiliation Department of Medicine, Division of Gastroenterology, Helsinki University Hospital, Helsinki, Finland

  ⨯
• Kimmo Kontula,

  Roles Resources

  Affiliation Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

  ⨯
• Aarno Palotie,

  Roles Data curation, Resources

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Neurology, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Steven R. Brant,

  Roles Resources

  Affiliations Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, United States of America, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America

  ⨯
• Richard H. Duerr,

  Roles Resources

  Affiliations Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States of America

  ⨯
• Mark S. Silverberg,

  Roles Resources

  Affiliation Inflammatory Bowel Disease Centre, Mount Sinai Hospital, Toronto, Ontario, Canada

  ⨯
• John D. Rioux,

  Roles Data curation, Resources

  Affiliations Research Center, Montreal Heart Institute, Montréal, Québec, Canada, Department of Medicine, Université de Montréal, Montréal, Québec, Canada

  http://orcid.org/0000-0001-7560-8326

  ⨯
• Rinse K. Weersma,

  Roles Data curation, Resources

  Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands

  ⨯
• Andre Franke,

  Roles Data curation, Resources

  Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany

  ⨯
• Luke Jostins,

  Roles Resources

  Affiliation Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom

  ⨯
• Carl A. Anderson,

  Roles Resources

  Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

  http://orcid.org/0000-0003-1719-7009

  ⨯
• Jeffrey C. Barrett,

  Roles Data curation, Resources

  Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

  ⨯
• Daniel G. MacArthur,

  Roles Data curation, Resources

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Chaim Jalas,

  Roles Resources

  Affiliation Bonei Olam, Center for Rare Jewish Genetic Disorders, Brooklyn, NY, United States of America

  ⨯
• Harry Sokol,

  Roles Resources

  Affiliation Gastroenterology Department, Saint-Antoine Hospital, AP-HP, UPMC Univ Paris, Paris, France

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• Ramnik J. Xavier,

  Roles Resources

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America

  ⨯
• Ann Pulver,

  Roles Resources

  Affiliation Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Judy H. Cho ,

  Roles Conceptualization, Investigation, Resources, Writing – review & editing

  * E-mail: mrivas@stanford.edu (MAR); judy.cho@mssm.edu (JHC); Dermot.McGovern@cshs.org (DPBM); mjdaly@atgu.mgh.harvard.edu (MJD)

  Affiliation Icahn School of Medicine at Mount Sinai, Dr Henry D. Janowitz Division of Gastroenterology, New York, NY, United States of America

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• Dermot P. B. McGovern ,

  Roles Conceptualization, Investigation, Resources, Writing – review & editing

  * E-mail: mrivas@stanford.edu (MAR); judy.cho@mssm.edu (JHC); Dermot.McGovern@cshs.org (DPBM); mjdaly@atgu.mgh.harvard.edu (MJD)

  Affiliation Translational Genomics Unit, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America

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•  [ ... ],
• Mark J. Daly

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: mrivas@stanford.edu (MAR); judy.cho@mssm.edu (JHC); Dermot.McGovern@cshs.org (DPBM); mjdaly@atgu.mgh.harvard.edu (MJD)

  Affiliations Medical and Population Genetics, Broad Institute, Cambridge, MA, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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