Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica

• Wing Lee Chan,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam Road, Hong Kong

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• Magdalena Steiner,

  Roles Conceptualization, Investigation, Methodology

  Affiliations Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, Berlin School for Regenerative Therapies (BSRT), Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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• Tomasz Witkos,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation School of Biology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0002-6568-4429

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• Johannes Egerer,

  Roles Investigation, Methodology

  Affiliation Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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• Björn Busse,

  Roles Investigation

  Current address: Lawrence Berkeley National Laboratory, Materials Sciences Division, University of California, Berkeley, Berkeley, California, United States of America

  Affiliation Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0002-3099-8073

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• Shuji Mizumoto,

  Roles Investigation, Methodology

  Current address: Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan

  Affiliation Lab. of Proteoglycan Signaling and Therapeutics, Faculty of Advanced Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan

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• Jan M. Pestka,

  Roles Investigation

  Current address: Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Freiburg, Germany

  Affiliation Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Haikuo Zhang,

  Roles Investigation

  Current address: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  Affiliation Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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• Ingrid Hausser,

  Roles Investigation

  Affiliation Institute of Pathology, University Clinic Heidelberg, Heidelberg, Germany

  http://orcid.org/0000-0002-1095-4962

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• Layal Abo Khayal,

  Roles Data curation, Investigation

  Affiliation Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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• Claus-Eric Ott,

  Roles Data curation, Supervision

  Affiliation Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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• Mateusz Kolanczyk,

  Roles Investigation

  Affiliation FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany

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• Bettina Willie,

  Roles Investigation, Supervision

  Current address: Research Center, Shriners Hospitals for Children-Canada, Department of Pediatric Surgery, McGill University, Montreal, Canada

  Affiliation Julius Wolff Institute, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

  http://orcid.org/0000-0003-2907-3580

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• Thorsten Schinke,

  Roles Conceptualization, Supervision

  Affiliation Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Chiara Paganini,

  Roles Investigation

  Affiliation Department of Molecular Medicine, Unit of Biochemistry, University of Pavia, Pavia, Italy

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• Antonio Rossi,

  Roles Investigation, Methodology, Supervision

  Affiliation Department of Molecular Medicine, Unit of Biochemistry, University of Pavia, Pavia, Italy

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• Kazuyuki Sugahara,

  Roles Investigation, Supervision

  Current address: Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan

  Affiliation Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Michael Amling,

  Roles Supervision

  Affiliation Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Petra Knaus,

  Roles Methodology, Supervision

  Affiliation Institute for Chemistry and Biochemistry, Freie Universität, Berlin, Germany

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• Danny Chan,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam Road, Hong Kong, The University of Hong Kong—Shenzhen Institute of Research and Innovation (HKU- SIRI), Hi-Tech Industrial Park, Nanshan, Shenzhen, China

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• Martin Lowe,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation School of Biology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0002-9331-8143

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• Stefan Mundlos ,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: uwe.kornak@charite.de (UK); stefan.mundlos@charite.de (SM)

  Affiliations Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany, Berlin-Brandenburg Center for Regenerative Therapies, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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•  [ ... ],
• Uwe Kornak

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: uwe.kornak@charite.de (UK); stefan.mundlos@charite.de (SM)

  Affiliations Institut für Medizinische Genetik und Humangenetik, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany, Berlin-Brandenburg Center for Regenerative Therapies, Charité –Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

  http://orcid.org/0000-0002-4582-9838

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