Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

Rui Zhang; Huimin Ma; Yuan Gao; Yanjun Wu; Yuemei Qiao; Ajun Geng; Cheguo Cai; Yingying Han; Yi Arial Zeng; Xiaolong Liu; Gaoxiang Ge

doi:10.1371/journal.pgen.1007211

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Open Access

Peer-reviewed

Research Article

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

Rui Zhang ,

Contributed equally to this work with: Rui Zhang, Huimin Ma, Yuan Gao

Roles Data curation, Formal analysis, Writing – original draft

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
⨯
Huimin Ma ,

Contributed equally to this work with: Rui Zhang, Huimin Ma, Yuan Gao

Roles Data curation, Formal analysis

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
⨯
Yuan Gao ,

Contributed equally to this work with: Rui Zhang, Huimin Ma, Yuan Gao

Roles Data curation, Formal analysis

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Yanjun Wu,

Roles Data curation, Formal analysis

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Yuemei Qiao,

Roles Data curation

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Ajun Geng,

Roles Methodology

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
⨯
Cheguo Cai,

Roles Methodology

Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Yingying Han,

Roles Data curation

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
⨯
Yi Arial Zeng,

Roles Resources

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
⨯
Xiaolong Liu ,

Roles Conceptualization, Writing – review & editing

* E-mail: gxge@sibcb.ac.cn (GG); liux@sibs.ac.cn (XL)

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China

http://orcid.org/0000-0001-7358-0366

⨯
Gaoxiang Ge

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: gxge@sibcb.ac.cn (GG); liux@sibs.ac.cn (XL)

Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People’s Republic of China

http://orcid.org/0000-0003-3189-8928

⨯

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

Rui Zhang,
Huimin Ma,
Yuan Gao,
Yanjun Wu,
Yuemei Qiao,
Ajun Geng,
Cheguo Cai,
Yingying Han,
Yi Arial Zeng,
Xiaolong Liu

Published: February 8, 2018
https://doi.org/10.1371/journal.pgen.1007211

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