Deep sequencing of HBV pre-S region reveals high heterogeneity of HBV genotypes and associations of word pattern frequencies with HCC

• Xin Bai ,

  Contributed equally to this work with: Xin Bai, Jian-an Jia

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliations Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-3755-0730

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• Jian-an Jia ,

  Contributed equally to this work with: Xin Bai, Jian-an Jia

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft

  Affiliations Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China, Department of Laboratory Medicine, the 105th Hospital of PLA, Hefei, China

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• Meng Fang,

  Roles Data curation, Investigation

  Affiliation Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

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• Shipeng Chen,

  Roles Data curation, Investigation

  Affiliation Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

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• Xiaotao Liang,

  Roles Visualization

  Affiliations Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China

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• Shanfeng Zhu,

  Roles Methodology, Visualization, Writing – review & editing

  Affiliation School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China

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• Shuqin Zhang,

  Roles Visualization, Writing – review & editing

  Affiliations Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, Shanghai Key Laboratory for Comtemporary Applied Mathematics, Fudan University, Shanghai, China

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• Jianfeng Feng,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, Department of Computer Science, University of Warwick, Coventry, United Kingodm

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• Fengzhu Sun ,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

  * E-mail: fsun@usc.edu (FS); gaocf1115@163.com (CG)

  Affiliations Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-8552-043X

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• Chunfang Gao

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  * E-mail: fsun@usc.edu (FS); gaocf1115@163.com (CG)

  Affiliation Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

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