Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila

• Yasufumi Sakakibara ,

  Roles Investigation, Writing – original draft, Writing – review & editing

  ¶‡ YS and MS share first authorship of this work.

  Affiliation Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

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• Michiko Sekiya ,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  ¶‡ YS and MS share first authorship of this work.

  Affiliation Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

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• Naoki Fujisaki,

  Roles Investigation

  Affiliations Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, Department of Experimental Gerontology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3–1 Tanabe-dori, Mizuho-ku, Nagoya, Japan

  http://orcid.org/0000-0002-9541-1405

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• Xiuming Quan,

  Roles Investigation

  Affiliation Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

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• Koichi M. Iijima

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: iijimakm@ncgg.go.jp

  Affiliations Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, Department of Experimental Gerontology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3–1 Tanabe-dori, Mizuho-ku, Nagoya, Japan

  http://orcid.org/0000-0003-4794-1863

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