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Open Access
Peer-reviewed
Research Article
HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression
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Alix Warburton,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Catherine J. Redmond,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization
Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Katharine E. Dooley,
Roles Investigation, Methodology
Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Haiqing Fu,
Roles Methodology
Affiliation Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Maura L. Gillison,
Roles Resources
Current address: Department of Thoracic/ Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
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Keiko Akagi,
Roles Data curation, Investigation, Methodology
Current address: Department of Thoracic/ Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Affiliation Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America
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David E. Symer,
Roles Investigation, Methodology, Supervision, Writing – review & editing
Current address: Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Affiliations Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America, Human Cancer Genetics Program, Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America, Department of Biomedical Informatics (adjunct), The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America
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Mirit I. Aladjem,
Roles Investigation, Methodology, Supervision, Writing – review & editing
Affiliation Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Alison A. McBride
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: amcbride@nih.gov
Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression
- Alix Warburton,
- Catherine J. Redmond,
- Katharine E. Dooley,
- Haiqing Fu,
- Maura L. Gillison,
- Keiko Akagi,
- David E. Symer,
- Mirit I. Aladjem,
- Alison A. McBride
![PLOS](/resource/img/logo-plos.png)
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- Published: January 24, 2018
- https://doi.org/10.1371/journal.pgen.1007179