Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics

Morgan N. Price; Grant M. Zane; Jennifer V. Kuehl; Ryan A. Melnyk; Judy D. Wall; Adam M. Deutschbauer; Adam P. Arkin

doi:10.1371/journal.pgen.1007147

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Open Access

Peer-reviewed

Research Article

Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics

Morgan N. Price ,

Roles Conceptualization, Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

* E-mail: morgannprice@yahoo.com (MNP); amdeutschbauer@lbl.gov (AMD); aparkin@lbl.gov (APA)

Affiliation Environmental Genomics & Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

http://orcid.org/0000-0002-4251-0362

⨯
Grant M. Zane,

Roles Investigation, Resources, Writing – review & editing

Affiliation Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America

http://orcid.org/0000-0002-3357-3097

⨯
Jennifer V. Kuehl,

Roles Investigation, Writing – review & editing

Affiliation Environmental Genomics & Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Ryan A. Melnyk,

Roles Resources

Affiliation Environmental Genomics & Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Judy D. Wall,

Roles Funding acquisition, Resources, Supervision

Affiliation Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America

http://orcid.org/0000-0002-9152-5544

⨯
Adam M. Deutschbauer ,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

* E-mail: morgannprice@yahoo.com (MNP); amdeutschbauer@lbl.gov (AMD); aparkin@lbl.gov (APA)

Affiliation Environmental Genomics & Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Adam P. Arkin

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: morgannprice@yahoo.com (MNP); amdeutschbauer@lbl.gov (AMD); aparkin@lbl.gov (APA)

Affiliation Environmental Genomics & Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯

Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics

Morgan N. Price,
Grant M. Zane,
Jennifer V. Kuehl,
Ryan A. Melnyk,
Judy D. Wall,
Adam M. Deutschbauer,
Adam P. Arkin

Published: January 11, 2018
https://doi.org/10.1371/journal.pgen.1007147
See the preprint

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Biosynthesis
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Methionine
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Chemical synthesis
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Vitamins
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Phosphatases
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Protein synthesis
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Serine
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Bacterial genomics
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