Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

Maria Victoria Fernández; Jong Hun Kim; John P. Budde; Kathleen Black; Alexandra Medvedeva; Ben Saef; Yuetiva Deming; Jorge Del-Aguila; Laura Ibañez; Umber Dube; Oscar Harari; Joanne Norton; Rachel Chasse; John C. Morris; Alison Goate; NIA-LOAD family study group; NCRAD; Carlos Cruchaga

doi:10.1371/journal.pgen.1007045

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Open Access

Peer-reviewed

Research Article

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

Maria Victoria Fernández,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
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Jong Hun Kim,

Roles Formal analysis

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America, Department of Neurology, Dementia Center, Ilsan hospital, National Health Insurance Service, Goyang, South Korea
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John P. Budde,

Roles Data curation, Software

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Kathleen Black,

Roles Methodology

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Alexandra Medvedeva,

Roles Methodology

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Ben Saef,

Roles Data curation

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Yuetiva Deming,

Roles Methodology

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America

http://orcid.org/0000-0001-7512-5703

⨯
Jorge Del-Aguila,

Roles Methodology

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Laura Ibañez,

Roles Methodology

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Umber Dube,

Roles Methodology

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America, Medical Scientist Training Program, Division of Biology and Biomedical sciences, School of Medicine, Washington University in Saint Louis, St. Louis, MO, United States of America
⨯
Oscar Harari,

Roles Methodology

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Joanne Norton,

Roles Data curation

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Rachel Chasse,

Roles Data curation

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America
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John C. Morris,

Roles Funding acquisition

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Alison Goate,

Roles Funding acquisition

Affiliation Ronald M. Loeb Center for Alzheimer’s disease, Dept of Neuroscience, Icahn School of Medicine at Mount Sinai, ICAHN 10–52, New York, NY, United States of America
⨯
NIA-LOAD family study group ,

¶Membership of the NIA-LOAD and NCRAD Family Study Group is provided in the Acknowledgments.
⨯
NCRAD ,

¶Membership of the NIA-LOAD and NCRAD Family Study Group is provided in the Acknowledgments.
⨯
[ ... ],
Carlos Cruchaga

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: cruchagac@wustl.edu

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States of America

http://orcid.org/0000-0002-0276-2899

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Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

Maria Victoria Fernández,
Jong Hun Kim,
John P. Budde,
Kathleen Black,
Alexandra Medvedeva,
Ben Saef,
Yuetiva Deming,
Jorge Del-Aguila,
Laura Ibañez,
Umber Dube

Published: November 1, 2017
https://doi.org/10.1371/journal.pgen.1007045

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