The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans

• Ritika Das ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing

  Current address: Department of Cell Biology, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, New York, United States of America

  ¶‡ RD made many of the initial findings and generated the majority of the data for this study. JAM generated additional data and made significant intellectual contributions and writing of the manuscript.

  Affiliations Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Biology, University of Rochester, Rochester, New York, United States of America

  http://orcid.org/0000-0002-4197-7382

  ⨯
• Justine A. Melo ,

  Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  ¶‡ RD made many of the initial findings and generated the majority of the data for this study. JAM generated additional data and made significant intellectual contributions and writing of the manuscript.

  Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America

  http://orcid.org/0000-0002-7476-0470

  ⨯
• Manjunatha Thondamal,

  Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization

  Current address: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus Gachibowli, Hyderabad, India

  Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America

  http://orcid.org/0000-0002-5089-6103

  ⨯
• Elizabeth A. Morton,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Adam B. Cornwell,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America

  ⨯
• Beresford Crick,

  Roles Investigation

  Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America

  ⨯
• Joung Heon Kim,

  Roles Formal analysis, Investigation

  Current address: Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America

  http://orcid.org/0000-0002-7168-8477

  ⨯
• Elliot W. Swartz,

  Roles Data curation, Investigation

  Current address: Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California, United States of America

  Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America

  http://orcid.org/0000-0003-1779-5631

  ⨯
• Todd Lamitina,

  Roles Formal analysis, Funding acquisition, Resources

  Affiliation Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Peter M. Douglas,

  Roles Conceptualization, Methodology, Resources

  Affiliation Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas, United States of America

  ⨯
• Andrew V. Samuelson

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Andrew_Samuelson@URMC.rochester.edu

  Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America

  http://orcid.org/0000-0002-3071-5766

  ⨯