p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

Francesco Napoletano; Benjamin Gibert; Keren Yacobi-Sharon; Stéphane Vincent; Clémentine Favrot; Patrick Mehlen; Victor Girard; Margaux Teil; Gilles Chatelain; Ludivine Walter; Eli Arama; Bertrand Mollereau

doi:10.1371/journal.pgen.1007024

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Peer-reviewed

Research Article

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

Francesco Napoletano,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Molecular Oncology Unit, Department of Life Sciences, University of Trieste c/o Laboratorio Nazionale CIB, Area Science Park, Trieste, Italy

Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France
⨯
Benjamin Gibert ,

Contributed equally to this work with: Benjamin Gibert, Keren Yacobi-Sharon

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization

Affiliation Apoptosis, Cancer and Development Laboratory- Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Centre Léon Bérard, Lyon, France
⨯
Keren Yacobi-Sharon ,

Contributed equally to this work with: Benjamin Gibert, Keren Yacobi-Sharon

Roles Conceptualization, Methodology, Resources

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯
Stéphane Vincent,

Roles Data curation, Formal analysis, Methodology

Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France
⨯
Clémentine Favrot,

Roles Data curation, Formal analysis, Methodology

Affiliation Apoptosis, Cancer and Development Laboratory- Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Centre Léon Bérard, Lyon, France
⨯
Patrick Mehlen,

Roles Funding acquisition, Resources

Affiliation Apoptosis, Cancer and Development Laboratory- Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Centre Léon Bérard, Lyon, France
⨯
Victor Girard,

Roles Data curation, Formal analysis

Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France
⨯
Margaux Teil,

Roles Data curation, Formal analysis

Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France

http://orcid.org/0000-0001-9677-5449

⨯
Gilles Chatelain,

Roles Data curation, Formal analysis, Methodology

Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France
⨯
Ludivine Walter,

Roles Formal analysis, Supervision, Validation, Writing – review & editing

Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France
⨯
Eli Arama,

Roles Methodology, Resources, Supervision

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯
Bertrand Mollereau

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bertrand.mollereau@ens-lyon.fr

Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France

http://orcid.org/0000-0003-4710-8185

⨯

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

Francesco Napoletano,
Benjamin Gibert,
Keren Yacobi-Sharon,
Stéphane Vincent,
Clémentine Favrot,
Patrick Mehlen,
Victor Girard,
Margaux Teil,
Gilles Chatelain,
Ludivine Walter

Published: September 25, 2017
https://doi.org/10.1371/journal.pgen.1007024

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Apoptosis
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Testes
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Necrosis
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Necrotic cell death
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Drosophila melanogaster
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Spermatogenesis
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Spermatogonia
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DAPI staining
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