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Open Access
Peer-reviewed
Research Article
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
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Niedzica Camacho,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
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Peter Van Loo,
Roles Methodology, Software, Supervision, Writing – original draft
Affiliations Cancer Genomics Laboratory, The Francis Crick Institute, London, United Kingdom, Department of Human Genetics, University of Leuven, Leuven, Belgium
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Sandra Edwards,
Roles Investigation, Project administration, Writing – review & editing
Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom
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Jonathan D. Kay,
Roles Investigation, Methodology
Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Molecular Diagnostics and Therapeutics Group, University College London, London, United Kingdom
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Lucy Matthews,
Roles Data curation, Investigation, Methodology
Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom
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Kerstin Haase,
Roles Formal analysis, Validation, Writing – review & editing
Affiliation Cancer Genomics Laboratory, The Francis Crick Institute, London, United Kingdom
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Jeremy Clark,
Roles Investigation, Methodology, Supervision, Writing – review & editing
Affiliation Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom
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Nening Dennis,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Sarah Thomas,
Roles Investigation, Project administration, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Barbara Kremeyer,
Roles Data curation, Formal analysis
Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
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Jorge Zamora,
Roles Data curation, Investigation, Software
Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
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Adam P. Butler,
Roles Project administration, Software, Supervision
Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
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Gunes Gundem,
Roles Data curation, Project administration
Affiliations Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom, Epidemiology & Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Sue Merson,
Roles Investigation, Resources
Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom
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Hayley Luxton,
Roles Investigation, Resources
Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Molecular Diagnostics and Therapeutics Group, University College London, London, United Kingdom
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Steve Hawkins,
Roles Investigation, Resources
Affiliation Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom
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Mohammed Ghori,
Roles Data curation, Project administration, Software
Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
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Luke Marsden,
Roles Investigation, Resources
Affiliation Department of Physiology, University of Oxford, Oxford, Oxfordshire, United Kingdom
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Adam Lambert,
Roles Investigation, Resources
Affiliation Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, Oxfordshire, United Kingdom
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Katalin Karaszi,
Roles Investigation, Resources
Affiliations Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, Oxfordshire, United Kingdom, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom
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Gill Pelvender,
Roles Investigation, Resources
Affiliation Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom
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Charlie E. Massie,
Roles Investigation, Project administration, Writing – review & editing
Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, CRUK Cambridge Centre, Early Detection Programme, Urological Malignancies Programme, Hutchison-MRC Research Centre, Cambridge, Cambridgeshire, United Kingdom
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Zsofia Kote-Jarai,
Roles Resources, Supervision
Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom
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Keiran Raine,
Roles Resources, Software
Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
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David Jones,
Roles Resources, Software
Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
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William J. Howat,
Roles Investigation, Resources
Affiliation Histopathology and in situ hybridization Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom
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Steven Hazell,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Naomi Livni,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Cyril Fisher,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Christopher Ogden,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Pardeep Kumar,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Alan Thompson,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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David Nicol,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Erik Mayer,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Tim Dudderidge,
Roles Investigation, Resources
Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Yongwei Yu,
Roles Investigation, Resources
Affiliation Department of Epidemiology, Second Military Medical University, Shanghai, China
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Hongwei Zhang,
Roles Investigation, Resources
Affiliation Department of Epidemiology, Second Military Medical University, Shanghai, China
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Nimish C. Shah,
Roles Investigation, Resources
Affiliation Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
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Vincent J. Gnanapragasam,
Roles Investigation, Resources, Supervision
Affiliation Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
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The CRUK-ICGC Prostate Group ,
¶Membership of the CRUK-ICGC Prostate Group is provided in
⨯S3 Appendix . -
William Isaacs,
Roles Resources
Affiliation School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
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Tapio Visakorpi,
Roles Data curation, Resources
Affiliation Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere and Tampere University Hospital, Tampere, Finland
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Freddie Hamdy,
Roles Investigation, Resources
Affiliation Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom
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Dan Berney,
Roles Investigation, Resources
Affiliation Centre for Molecular Oncology, Barts Cancer Institute, The Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
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Clare Verrill,
Roles Investigation, Resources
Affiliation Department of Cellular Pathology and Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, United Kingdom
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Anne Y. Warren,
Roles Investigation, Resources
Affiliation Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
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David C. Wedge,
Roles Project administration, Resources, Supervision, Writing – review & editing
Affiliations Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom, Oxford Big Data Institute & Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, Oxford, Oxfordshire, United Kingdom
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Andrew G. Lynch ,
Roles Investigation, Project administration, Resources, Writing – review & editing
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliations Statistics and Computational Biology Laboratory, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, School of Mathematics and Statistics/School of Medicine, University of St Andrews, St Andrews, Fife, Scotland
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Christopher S. Foster ,
Roles Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliation HCA Pathology Laboratories, HCA Healthcare, London, United Kingdom
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Yong Jie Lu,
Roles Data curation, Investigation, Resources, Writing – review & editing
Affiliation Centre for Molecular Oncology, Barts Cancer Institute, The Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
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G. Steven Bova ,
Roles Investigation, Resources, Supervision, Writing – review & editing
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliation Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere and Tampere University Hospital, Tampere, Finland
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Hayley C. Whitaker,
Roles Investigation, Resources, Supervision
Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Molecular Diagnostics and Therapeutics Group, University College London, London, United Kingdom
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Ultan McDermott ,
Roles Funding acquisition, Investigation, Resources, Supervision
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
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David E. Neal ,
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
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Rosalind Eeles ,
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliations Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom, Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
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Colin S. Cooper ,
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliations Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom, Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom
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Daniel S. Brewer
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: d.brewer@uea.ac.uk
¶‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.
Affiliations Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom, Organisms and Ecosystems, The Earlham Institute, Norwich, Norfolk, United Kingdom
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Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
- Niedzica Camacho,
- Peter Van Loo,
- Sandra Edwards,
- Jonathan D. Kay,
- Lucy Matthews,
- Kerstin Haase,
- Jeremy Clark,
- Nening Dennis,
- Sarah Thomas,
- Barbara Kremeyer
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- Published: September 25, 2017
- https://doi.org/10.1371/journal.pgen.1007001