Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

• Stefan Zdraljevic,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

  http://orcid.org/0000-0003-2883-4616

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• Christine Strand,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0001-5783-6667

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• Hannah S. Seidel,

  Roles Resources, Writing – original draft

  Affiliation Biology Department, Eastern Michigan University, Ypsilanti, Michigan, United States of America

  http://orcid.org/0000-0002-4831-8646

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• Daniel E. Cook,

  Roles Data curation, Resources, Software

  Affiliations Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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• John G. Doench,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-3707-9889

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• Erik C. Andersen

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Erik.Andersen@Northwestern.edu

  Affiliations Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, United States of America

  http://orcid.org/0000-0003-0229-9651

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