The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Tobias Wilms; Erwin Swinnen; Elja Eskes; Laura Dolz-Edo; Alice Uwineza; Ruben Van Essche; Joëlle Rosseels; Piotr Zabrocki; Elisabetta Cameroni; Vanessa Franssens; Claudio De Virgilio; Gertien J. Smits; Joris Winderickx

doi:10.1371/journal.pgen.1006835

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Open Access

Peer-reviewed

Research Article

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Tobias Wilms ,

Contributed equally to this work with: Tobias Wilms, Erwin Swinnen

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium
⨯
Erwin Swinnen ,

Contributed equally to this work with: Tobias Wilms, Erwin Swinnen

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium
⨯
Elja Eskes,

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium

http://orcid.org/0000-0003-1678-0323

⨯
Laura Dolz-Edo,

Affiliation Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, GE Amsterdam, The Netherlands
⨯
Alice Uwineza,

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium
⨯
Ruben Van Essche,

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium
⨯
Joëlle Rosseels,

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium
⨯
Piotr Zabrocki,

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium
⨯
Elisabetta Cameroni,

Current address: Humabs Biomed SA, Bellinzona, Switzerland

Affiliation Department of Biology, University of Fribourg, Fribourg, Switzerland
⨯
Vanessa Franssens,

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium

http://orcid.org/0000-0003-3679-8344

⨯
Claudio De Virgilio,

Affiliation Department of Biology, University of Fribourg, Fribourg, Switzerland
⨯
Gertien J. Smits,

Affiliation Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, GE Amsterdam, The Netherlands

http://orcid.org/0000-0002-8439-7791

⨯
Joris Winderickx

* E-mail: joris.winderickx@kuleuven.be

Affiliation Department of Biology, Functional Biology, KU Leuven, Heverlee, Belgium
⨯

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Tobias Wilms,
Erwin Swinnen,
Elja Eskes,
Laura Dolz-Edo,
Alice Uwineza,
Ruben Van Essche,
Joëlle Rosseels,
Piotr Zabrocki,
Elisabetta Cameroni,
Vanessa Franssens

Published: June 12, 2017
https://doi.org/10.1371/journal.pgen.1006835

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