p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

Rose Richardson; Karen Mitchell; Nigel L. Hammond; Maria Rosaria Mollo; Evelyn N. Kouwenhoven; Niki D. Wyatt; Ian J. Donaldson; Leo Zeef; Tim Burgis; Rognvald Blance; Simon J. van Heeringen; Hendrik G. Stunnenberg; Huiqing Zhou; Caterina Missero; Rose Anne Romano; Satrajit Sinha; Michael J. Dixon; Jill Dixon

doi:10.1371/journal.pgen.1006828

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Peer-reviewed

Research Article

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

Rose Richardson ,

¶‡ These authors share first authorship on this work.

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Karen Mitchell ,

¶‡ These authors share first authorship on this work.

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Nigel L. Hammond,

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Maria Rosaria Mollo,

Affiliation CEINGE Biotecnologie Avanzate Scarl (Center for Genetic Engineering), Napoli, Italy
⨯
Evelyn N. Kouwenhoven,

Affiliation Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
⨯
Niki D. Wyatt,

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Ian J. Donaldson,

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Leo Zeef,

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Tim Burgis,

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Rognvald Blance,

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
Simon J. van Heeringen,

Affiliation Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands

http://orcid.org/0000-0002-0411-3219

⨯
Hendrik G. Stunnenberg,

Affiliation Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
⨯
Huiqing Zhou,

Affiliations Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Caterina Missero,

Affiliations CEINGE Biotecnologie Avanzate Scarl (Center for Genetic Engineering), Napoli, Italy, Department of Biology, University of Naples, Federico II, Napoli, Italy
⨯
Rose Anne Romano,

Affiliation Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York, United States of America
⨯
Satrajit Sinha,

Affiliation Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America
⨯
Michael J. Dixon ,

* E-mail: jill.dixon@manchester.ac.uk (JD); mike.dixon@manchester.ac.uk (MD)

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
⨯
[ ... ],
Jill Dixon

* E-mail: jill.dixon@manchester.ac.uk (JD); mike.dixon@manchester.ac.uk (MD)

Affiliation Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom

http://orcid.org/0000-0001-9774-7095

⨯
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p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

Rose Richardson,
Karen Mitchell,
Nigel L. Hammond,
Maria Rosaria Mollo,
Evelyn N. Kouwenhoven,
Niki D. Wyatt,
Ian J. Donaldson,
Leo Zeef,
Tim Burgis,
Rognvald Blance

Published: June 12, 2017
https://doi.org/10.1371/journal.pgen.1006828

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Cleft palate
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Palate
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Cell fusion
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Keratins
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Microarrays
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Epithelial cells
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Immunostaining
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Transcriptional control
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