Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

• He Li,

  Current address: Institute for Genomic Medicine, University of California, San Diego, La Jolla, California, United States of America

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

  ⨯
• Tove Ragna Reksten,

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway

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• John A. Ice,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  ⨯
• Jennifer A. Kelly,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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• Indra Adrianto,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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• Astrid Rasmussen,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  http://orcid.org/0000-0001-7744-2948

  ⨯
• Shaofeng Wang,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  ⨯
• Bo He,

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

  ⨯
• Kiely M. Grundahl,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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• Stuart B. Glenn,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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• Corinne Miceli-Richard,

  Affiliation Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, INSERM U1012, Le Kremlin Bicêtre, France

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• Simon Bowman,

  Affiliation Rheumatology Department, University Hospital Birmingham, Birmingham, United Kingdom

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• Sue Lester,

  Affiliation The Queen Elizabeth Hospital, Adelaide, South Australia, Australia

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• Per Eriksson,

  Affiliation Department of Rheumatology, Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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• Maija-Leena Eloranta,

  Affiliation Department of Medical Sciences, Rheumatology, SciLIfeLab, Uppsala University, Uppsala, Sweden

  http://orcid.org/0000-0002-8454-1351

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• Johan G. Brun,

  Affiliations Department of Clinical Science, University of Bergen, Bergen, Norway, Department of Rheumatology, Haukeland University Hospital, Bergen, Norway

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• Lasse G. Gøransson,

  Affiliation Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway

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• Erna Harboe,

  Affiliation Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway

  ⨯
• Joel M. Guthridge,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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• Kenneth M. Kaufman,

  Affiliations Division of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America

  http://orcid.org/0000-0001-8195-1876

  ⨯
• Marika Kvarnström,

  Affiliation Department of Medicine, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-4948-8380

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• Deborah S. Cunninghame Graham,

  Affiliation Department of Medical and Molecular Genetics, King's College London, London, United Kingdom

  http://orcid.org/0000-0002-3066-6693

  ⨯
• Ketan Patel,

  Affiliations Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America, Department of Oral and Maxillofacial Surgery, North Memorial Medical Center, Robbinsdale, Minnesota, United States of America

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• Adam J. Adler,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  ⨯
• A. Darise Farris,

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

  ⨯
• Michael T. Brennan,

  Affiliation Department of Oral Medicine, Carolinas Medical Center, Charlotte, North Carolina, United States of America

  ⨯
• James Chodosh,

  Affiliation Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Rajaram Gopalakrishnan,

  Affiliation Division of Oral Pathology, Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America

  ⨯
• Michael H. Weisman,

  Affiliation Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  ⨯
• Swamy Venuturupalli,

  Affiliation Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  ⨯
• Daniel J. Wallace,

  Affiliation Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  ⨯
• Kimberly S. Hefner,

  Affiliation Hefner Eye Care and Optical Center, Oklahoma City, Oklahoma, United States of America

  ⨯
• Glen D. Houston,

  Affiliations Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, Oklahoma, United States of America, Heartland Pathology Consultants, Edmond, Oklahoma, United States of America

  ⨯
• Andrew J. W. Huang,

  Affiliation Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, Missouri, United States of America

  http://orcid.org/0000-0003-1939-9149

  ⨯
• Pamela J. Hughes,

  Affiliation Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America

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• David M. Lewis,

  Affiliation Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, Oklahoma, United States of America

  ⨯
• Lida Radfar,

  Affiliation Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, Oklahoma, United States of America

  ⨯
• Evan S. Vista,

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, University of Santo Tomas Hospital, Manila, The Philippines

  ⨯
• Contessa E. Edgar,

  Affiliation The Biology Department, Oklahoma Baptist University, Oklahoma City, Oklahoma, United States of America

  http://orcid.org/0000-0001-9701-0886

  ⨯
• Michael D. Rohrer,

  Affiliation Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America

  ⨯
• Donald U. Stone,

  Affiliation Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland, United States of America

  ⨯
• Timothy J. Vyse,

  Affiliation Department of Medical and Molecular Genetics, King's College London, London, United Kingdom

  ⨯
• John B. Harley,

  Affiliations Division of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America

  ⨯
• Patrick M. Gaffney,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  http://orcid.org/0000-0002-1580-869X

  ⨯
• Judith A. James,

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

  ⨯
• Sean Turner,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  ⨯
• Ilias Alevizos,

  Affiliation National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, United States of America

  ⨯
• Juan-Manuel Anaya,

  Affiliation Center for Autoimmune Diseases Research, Universidad del Rosario, Bogotá, Colombia

  ⨯
• Nelson L. Rhodus,

  Affiliation Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America

  ⨯
• Barbara M. Segal,

  Affiliation Division of Rheumatology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

  ⨯
• Courtney G. Montgomery,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  ⨯
• R. Hal Scofield,

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, United States of America

  ⨯
• Susan Kovats,

  Affiliation Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

  ⨯
• Xavier Mariette,

  Affiliation Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, INSERM U1012, Le Kremlin Bicêtre, France

  ⨯
• Lars Rönnblom,

  Affiliation Department of Medical Sciences, Rheumatology, SciLIfeLab, Uppsala University, Uppsala, Sweden

  http://orcid.org/0000-0001-9403-6503

  ⨯
• Torsten Witte,

  Affiliation Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany

  ⨯
• Maureen Rischmueller,

  Affiliations The Queen Elizabeth Hospital, Adelaide, South Australia, Australia, The University of Adelaide, Adelaide, South Australia, Australia

  ⨯
• Marie Wahren-Herlenius,

  Affiliation Department of Medicine, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-0915-7245

  ⨯
• Roald Omdal,

  Affiliation Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway

  ⨯
• Roland Jonsson,

  Affiliations Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, Department of Rheumatology, Haukeland University Hospital, Bergen, Norway

  http://orcid.org/0000-0002-9588-0260

  ⨯
• Wan-Fai Ng,

  Affiliation Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

  http://orcid.org/0000-0002-5539-388X

  ⨯
• for UK Primary Sjögren's Syndrome Registry ,

  ¶Membership of UK Primary Sjögren's Syndrome Registry is provided in S1 Text

  ⨯
• Gunnel Nordmark,

  Affiliation Department of Medical Sciences, Rheumatology, SciLIfeLab, Uppsala University, Uppsala, Sweden

  http://orcid.org/0000-0002-3829-7431

  ⨯
• Christopher J. Lessard ,

  ¶‡ These are joint senior authors on this work.

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

  ⨯
•  [ ... ],
• Kathy L. Sivils

  * E-mail: sivilsk@omrf.org

  ¶‡ These are joint senior authors on this work.

  Affiliations Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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