Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia

Jun-Ho Cho; Goo-Young Kim; Chi-Jiunn Pan; Javier Anduaga; Eui-Ju Choi; Brian C. Mansfield; Janice Y. Chou

doi:10.1371/journal.pgen.1006819

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Peer-reviewed

Research Article

Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia

Jun-Ho Cho,

Affiliation Section on Cellular Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Goo-Young Kim,

Affiliation Section on Cellular Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Chi-Jiunn Pan,

Affiliation Section on Cellular Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Javier Anduaga,

Affiliation Section on Cellular Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Eui-Ju Choi,

Affiliation Laboratory of Cell Death and Human Diseases, Department of Life Sciences, Korea University, Seoul, South Korea

http://orcid.org/0000-0002-3642-0432

⨯
Brian C. Mansfield,

Affiliations Section on Cellular Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, Foundation Fighting Blindness, Columbia, Maryland, United States of America
⨯
Janice Y. Chou

* E-mail: chouja@mail.nih.gov

Affiliation Section on Cellular Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

http://orcid.org/0000-0003-4004-6516

⨯

Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia

Jun-Ho Cho,
Goo-Young Kim,
Chi-Jiunn Pan,
Javier Anduaga,
Eui-Ju Choi,
Brian C. Mansfield,
Janice Y. Chou

Published: May 30, 2017
https://doi.org/10.1371/journal.pgen.1006819

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Fatty liver
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Vesicles
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Glucose metabolism
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Immunoprecipitation
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Hepatocytes
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