Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

• Dmitry Shungin ,

  Contributed equally to this work with: Dmitry Shungin, Wei Q. Deng, Guillaume Paré, Paul W. Franks

  Affiliations Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden, Department of Odontology, Umeå University, Umeå, Sweden, Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States of America

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• Wei Q. Deng ,

  Contributed equally to this work with: Dmitry Shungin, Wei Q. Deng, Guillaume Paré, Paul W. Franks

  Affiliation Department of Statistical Sciences, University of Toronto, Toronto, Canada

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• Tibor V. Varga,

  Affiliations Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden, Novo Nordisk Foundation Center for Protein Research, Translational Disease Systems Biology Group, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Health Sciences, Exercise Physiology Group, Lund University, Lund, Sweden

  http://orcid.org/0000-0002-2383-699X

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• Jian'an Luan,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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• Evelin Mihailov,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Andres Metspalu,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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• GIANT Consortium ,

  ¶GIANT Consortium contributors and their affiliations are listed in S1 Text

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• Andrew P. Morris,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

  http://orcid.org/0000-0002-6805-6014

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• Nita G. Forouhi,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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• Cecilia Lindgren,

  Affiliations Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States of America, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0002-4903-9374

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• Patrik K. E. Magnusson,

  Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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• Nancy L. Pedersen,

  Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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• Göran Hallmans,

  Affiliation Department of Biobank Research, Umeå University, Umeå, Sweden

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• Audrey Y. Chu,

  Affiliation Harvard Medical School, Boston, MA, United States of America

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• Anne E. Justice,

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

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• Mariaelisa Graff,

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

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• Thomas W. Winkler,

  Affiliation Department of Genetic Epidemiology, University of Regensburg, Regensburg, DE, Germany

  http://orcid.org/0000-0003-0292-5421

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• Lynda M. Rose,

  Affiliation Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America

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• Claudia Langenberg,

  Affiliations MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom, Department of Epidemiology and Public Health, UCL London, United Kingdom

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• L. Adrienne Cupples,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, The NHLBI Framingham Heart Study, Framingham, MA

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• Paul M. Ridker,

  Affiliations Harvard Medical School, Boston, MA, United States of America, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America

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• Nicholas J. Wareham,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

  http://orcid.org/0000-0003-1422-2993

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• Ken K. Ong,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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• Ruth J. F. Loos,

  Affiliations The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY

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• Daniel I. Chasman,

  Affiliations Harvard Medical School, Boston, MA, United States of America, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America

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• Erik Ingelsson,

  Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden, Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States of America

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• Tuomas O. Kilpeläinen,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Robert A. Scott,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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• Reedik Mägi,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Guillaume Paré ,

  Contributed equally to this work with: Dmitry Shungin, Wei Q. Deng, Guillaume Paré, Paul W. Franks

  * E-mail: paul.franks@med.lu.se (PWF); pareg@mcmaster.ca (GP)

  Affiliation Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada

  http://orcid.org/0000-0002-6795-4760

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•  [ ... ],
• Paul W. Franks

  Contributed equally to this work with: Dmitry Shungin, Wei Q. Deng, Guillaume Paré, Paul W. Franks

  * E-mail: paul.franks@med.lu.se (PWF); pareg@mcmaster.ca (GP)

  Affiliations Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden, Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden, Department of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts, United States of America, Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliff Department of Medicine, University of Oxford, Oxford, United Kingdom

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