Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

Jackson Champer; Riona Reeves; Suh Yeon Oh; Chen Liu; Jingxian Liu; Andrew G. Clark; Philipp W. Messer

doi:10.1371/journal.pgen.1006796

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Open Access

Peer-reviewed

Research Article

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

Jackson Champer ,

* E-mail: jc3248@cornell.edu (JC); messer@cornell.edu (PWM)

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States of America

http://orcid.org/0000-0002-3814-3774

⨯
Riona Reeves,

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States of America

http://orcid.org/0000-0003-0236-4046

⨯
Suh Yeon Oh,

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States of America

http://orcid.org/0000-0002-6908-9336

⨯
Chen Liu,

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States of America
⨯
Jingxian Liu,

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States of America

http://orcid.org/0000-0002-2172-3297

⨯
Andrew G. Clark,

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States of America

http://orcid.org/0000-0001-7159-8511

⨯
Philipp W. Messer

* E-mail: jc3248@cornell.edu (JC); messer@cornell.edu (PWM)

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, United States of America

http://orcid.org/0000-0001-8453-9377

⨯

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

Jackson Champer,
Riona Reeves,
Suh Yeon Oh,
Chen Liu,
Jingxian Liu,
Andrew G. Clark,
Philipp W. Messer

Published: July 20, 2017
https://doi.org/10.1371/journal.pgen.1006796

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