Identifying pathogenicity of human variants via paralog-based yeast complementation

• Fan Yang,

  Affiliations Donnelly Centre, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

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• Song Sun,

  Affiliations Donnelly Centre, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

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• Guihong Tan,

  Affiliations Donnelly Centre, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Michael Costanzo,

  Affiliations Donnelly Centre, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• David E. Hill,

  Affiliations Center for Cancer Systems Biology (CCSB), Dana- Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0001-5192-0921

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• Marc Vidal,

  Affiliations Center for Cancer Systems Biology (CCSB), Dana- Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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• Brenda J. Andrews,

  Affiliations Donnelly Centre, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Charles Boone,

  Affiliations Donnelly Centre, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Canadian Institute for Advanced Research, Toronto, Ontario, Canada

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• Frederick P. Roth

  * E-mail: fritz.roth@utoronto.ca

  Affiliations Donnelly Centre, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, Center for Cancer Systems Biology (CCSB), Dana- Farber Cancer Institute, Boston, Massachusetts, United States of America, Canadian Institute for Advanced Research, Toronto, Ontario, Canada

  http://orcid.org/0000-0002-6628-649X

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