Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice

Sayantani Sinha; Christina Mundy; Till Bechtold; Federica Sgariglia; Mazen M. Ibrahim; Paul C. Billings; Kristen Carroll; Eiki Koyama; Kevin B. Jones; Maurizio Pacifici

doi:10.1371/journal.pgen.1006742

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Peer-reviewed

Research Article

Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice

Sayantani Sinha ,

Contributed equally to this work with: Sayantani Sinha, Christina Mundy, Till Bechtold

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Christina Mundy ,

Contributed equally to this work with: Sayantani Sinha, Christina Mundy, Till Bechtold

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Till Bechtold ,

Contributed equally to this work with: Sayantani Sinha, Christina Mundy, Till Bechtold

Current address: Department of Orthodontics and Orofacial Orthopedics, University Hospital Tuebingen, Tuebingen, Germany

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Federica Sgariglia,

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Mazen M. Ibrahim,

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Paul C. Billings,

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Kristen Carroll,

Affiliations Shriner’s Hospital for Children, Salt Lake City, Utah, United States of America, Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

http://orcid.org/0000-0001-8140-6595

⨯
Eiki Koyama,

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Kevin B. Jones ,

* E-mail: pacificim@email.chop.edu (MP); kevin.jones@hci.utah.edu (KBJ)

Affiliations Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Maurizio Pacifici

* E-mail: pacificim@email.chop.edu (MP); kevin.jones@hci.utah.edu (KBJ)

Affiliation Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0001-6854-4942

⨯

Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice

Sayantani Sinha,
Christina Mundy,
Till Bechtold,
Federica Sgariglia,
Mazen M. Ibrahim,
Paul C. Billings,
Kristen Carroll,
Eiki Koyama,
Kevin B. Jones,
Maurizio Pacifici

Published: April 26, 2017
https://doi.org/10.1371/journal.pgen.1006742

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