Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Sofie V. Nielsen; Amelie Stein; Alexander B. Dinitzen; Elena Papaleo; Michael H. Tatham; Esben G. Poulsen; Maher M. Kassem; Lene J. Rasmussen; Kresten Lindorff-Larsen; Rasmus Hartmann-Petersen

doi:10.1371/journal.pgen.1006739

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Open Access

Peer-reviewed

Research Article

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Sofie V. Nielsen,

Affiliation The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark
⨯
Amelie Stein,

Affiliation The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark

http://orcid.org/0000-0002-5862-1681

⨯
Alexander B. Dinitzen,

Affiliation The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark
⨯
Elena Papaleo,

Affiliation Computational Biology Laboratory, Unit of Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, Denmark
⨯
Michael H. Tatham,

Affiliation Centre for Gene Regulation and Expression, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, United Kingdom

http://orcid.org/0000-0001-6986-1691

⨯
Esben G. Poulsen,

Affiliation The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark
⨯
Maher M. Kassem,

Affiliation The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark
⨯
Lene J. Rasmussen,

Affiliation Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark
⨯
Kresten Lindorff-Larsen ,

* E-mail: lindorff@bio.ku.dk (KLL); rhpetersen@bio.ku.dk (RHP)

Affiliation The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark

http://orcid.org/0000-0002-4750-6039

⨯
Rasmus Hartmann-Petersen

* E-mail: lindorff@bio.ku.dk (KLL); rhpetersen@bio.ku.dk (RHP)

Affiliation The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark

http://orcid.org/0000-0002-4155-7791

⨯

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Sofie V. Nielsen,
Amelie Stein,
Alexander B. Dinitzen,
Elena Papaleo,
Michael H. Tatham,
Esben G. Poulsen,
Maher M. Kassem,
Lene J. Rasmussen,
Kresten Lindorff-Larsen,
Rasmus Hartmann-Petersen

Published: April 19, 2017
https://doi.org/10.1371/journal.pgen.1006739

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