Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions

Supriya Sinha; Fuyang Li; Diana Villarreal; Jae Hoon Shim; Suhyeon Yoon; Kyungjae Myung; Eun Yong Shim; Sang Eun Lee

doi:10.1371/journal.pgen.1006714

Loading metrics

Open Access

Peer-reviewed

Research Article

Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions

Supriya Sinha,

Affiliation Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America

http://orcid.org/0000-0001-7315-6063

⨯
Fuyang Li,

Affiliation Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America
⨯
Diana Villarreal,

Affiliation Children's Hospital of San Antonio, Baylor College of Medicine, San Antonio, TX, United States of America
⨯
Jae Hoon Shim,

Affiliation Korea Institute of Radiological & Medical Sciences (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul, Republic of Korea
⨯
Suhyeon Yoon,

Affiliation Department of Biological Science, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44818, Republic of Korea

http://orcid.org/0000-0002-3883-8330

⨯
Kyungjae Myung,

Affiliations Center for Genomic Integrity, Institute for Basic Science, Ulsan 44818, Republic of Korea, Department of Biological Science, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44818, Republic of Korea
⨯
Eun Yong Shim,

Affiliation Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America
⨯
Sang Eun Lee

* E-mail: lees4@uthscsa.edu

Affiliations Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America, Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America
⨯

Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions

Supriya Sinha,
Fuyang Li,
Diana Villarreal,
Jae Hoon Shim,
Suhyeon Yoon,
Kyungjae Myung,
Eun Yong Shim,
Sang Eun Lee

Published: April 18, 2017
https://doi.org/10.1371/journal.pgen.1006714

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA repair
Is the Subject Area "DNA repair" applicable to this article?

Thanks for your feedback.
Microhomology-mediated end joining
Is the Subject Area "Microhomology-mediated end joining" applicable to this article?

Thanks for your feedback.
Mutagenesis
Is the Subject Area "Mutagenesis" applicable to this article?

Thanks for your feedback.
Galactose
Is the Subject Area "Galactose" applicable to this article?

Thanks for your feedback.
Chromosomal translocations
Is the Subject Area "Chromosomal translocations" applicable to this article?

Thanks for your feedback.
Insertion mutation
Is the Subject Area "Insertion mutation" applicable to this article?

Thanks for your feedback.
Yeast
Is the Subject Area "Yeast" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.