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Open Access
Peer-reviewed
Research Article
Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans
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Christopher F. Bennett,
Affiliations Department of Pathology, University of Washington, Seattle, WA, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, WA, United States of America
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Jane J. Kwon,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Christine Chen,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Joshua Russell,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Kathlyn Acosta,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Nikolay Burnaevskiy,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Matthew M. Crane,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Alessandro Bitto,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Helen Vander Wende,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Marissa Simko,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Victor Pineda,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Ryan Rossner,
Affiliations Department of Pathology, University of Washington, Seattle, WA, United States of America, Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA, United States of America
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Brian M. Wasko,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Haeri Choi,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Shiwen Chen,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Shirley Park,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Gholamali Jafari,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Bryan Sands,
Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
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Carissa Perez Olsen,
Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
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Alexander R. Mendenhall,
Affiliation Department of Pathology, University of Washington, Seattle, WA, United States of America
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Philip G. Morgan,
Affiliations Center for Integrated Brain Research, Seattle Children’s Research Institute, Seattle, WA, United States of America, Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA, United States of America
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Matt Kaeberlein
* E-mail: kaeber@uw.edu
Affiliations Department of Pathology, University of Washington, Seattle, WA, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, WA, United States of America, Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA, United States of America
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Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans
- Christopher F. Bennett,
- Jane J. Kwon,
- Christine Chen,
- Joshua Russell,
- Kathlyn Acosta,
- Nikolay Burnaevskiy,
- Matthew M. Crane,
- Alessandro Bitto,
- Helen Vander Wende,
- Marissa Simko
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- Published: March 29, 2017
- https://doi.org/10.1371/journal.pgen.1006695