Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases

Rachel A. Kline; Kevin A. Kaifer; Erkan Y. Osman; Francesco Carella; Ariana Tiberi; Jolill Ross; Giuseppa Pennetta; Christian L. Lorson; Lyndsay M. Murray

doi:10.1371/journal.pgen.1006680

Loading metrics

Open Access

Peer-reviewed

Research Article

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases

Rachel A. Kline,

Affiliations Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, United Kingdom

http://orcid.org/0000-0002-1692-2208

⨯
Kevin A. Kaifer,

Affiliation Bond Life Sciences Center, University of Missouri, Columbia, Missouri, United States of America
⨯
Erkan Y. Osman,

Affiliations Bond Life Sciences Center, University of Missouri, Columbia, Missouri, United States of America, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Francesco Carella,

Affiliations Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, United Kingdom
⨯
Ariana Tiberi,

Affiliation Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
⨯
Jolill Ross,

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Giuseppa Pennetta,

Affiliations Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, United Kingdom
⨯
Christian L. Lorson,

Affiliations Bond Life Sciences Center, University of Missouri, Columbia, Missouri, United States of America, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Lyndsay M. Murray

* E-mail: Lyndsay.Murray@ed.ac.uk

Affiliations Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, United Kingdom

http://orcid.org/0000-0001-6841-702X

⨯

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases

Rachel A. Kline,
Kevin A. Kaifer,
Erkan Y. Osman,
Francesco Carella,
Ariana Tiberi,
Jolill Ross,
Giuseppa Pennetta,
Christian L. Lorson,
Lyndsay M. Murray

Published: March 31, 2017
https://doi.org/10.1371/journal.pgen.1006680

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Motor neurons
Is the Subject Area "Motor neurons" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Motor neuron diseases
Is the Subject Area "Motor neuron diseases" applicable to this article?

Thanks for your feedback.
Drosophila melanogaster
Is the Subject Area "Drosophila melanogaster" applicable to this article?

Thanks for your feedback.
Animal models of disease
Is the Subject Area "Animal models of disease" applicable to this article?

Thanks for your feedback.
Abdominal muscles
Is the Subject Area "Abdominal muscles" applicable to this article?

Thanks for your feedback.
Neuromuscular junctions
Is the Subject Area "Neuromuscular junctions" applicable to this article?

Thanks for your feedback.
Eyes
Is the Subject Area "Eyes" applicable to this article?

Thanks for your feedback.